Amrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham, Kochi-682041, India.
J Biomed Nanotechnol. 2012 Dec;8(6):891-900. doi: 10.1166/jbn.2012.1461.
We developed chitin hydrogel/nano ZnO composite bandages using chitin hydrogel and ZnO nanoparticles (nZnO). The homogenized mixture of chitin hydrogel and nZnO was freeze-dried to obtain micro-porous composite bandages. The prepared nanocomposite bandages were characterized using FT-IR, XRD and SEM. In addition, blood clotting, antibacterial, swelling, cytocompatibility and cell attachment capability of the prepared nanocomposite bandages were evaluated. The nanocomposite bandages showed enhanced swelling, blood clotting and antibacterial activity. The incorporation of nZnO helped to attain antibacterial activity. Cytocompatibility studies were carried out using human dermal fibroblast (HDF) cells proved the non-toxic nature of the composite bandages. HDF cell attachment and infiltration analysis showed that the cells were attached and penetrated into the interior (250 microm) of the nanocomposite bandages. These studies revealed that, this nanocomposite can be used for burn, diabetic and chronic wound defects.
我们使用壳聚糖水凝胶和氧化锌纳米粒子（nZnO）开发了壳聚糖水凝胶/纳米 ZnO 复合绷带。壳聚糖水凝胶和 nZnO 的均匀混合物经冷冻干燥得到微孔复合绷带。采用傅里叶变换红外光谱（FT-IR）、X 射线衍射（XRD）和扫描电子显微镜（SEM）对制备的纳米复合材料进行了表征。此外，还评价了制备的纳米复合材料的止血、抗菌、溶胀、细胞相容性和细胞附着能力。纳米复合材料具有增强的溶胀、止血和抗菌活性。nZnO 的掺入有助于获得抗菌活性。使用人皮肤成纤维细胞（HDF）进行的细胞相容性研究证明了复合绷带的无毒性质。HDF 细胞附着和渗透分析表明，细胞附着并渗透到纳米复合材料的内部（250μm）。这些研究表明，这种纳米复合材料可用于烧伤、糖尿病和慢性伤口缺陷。
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