疟原虫是否操纵蚊子？
Do malaria parasites manipulate mosquitoes?
机构信息
Center for Infectious Disease Dynamics, Department of Entomology, Pennsylvania State University, University Park, PA, USA.
出版信息
Trends Parasitol. 2012 Nov;28(11):466-70. doi: 10.1016/j.pt.2012.08.004. Epub 2012 Oct 6.
Abstract
Malaria parasites have been suggested to alter the behavior of mosquito vectors to increase the likelihood of transmission. Some empirical evidence supports this hypothesis, yet the role of manipulation is ignored in most epidemiological models, and behavioral differences between infected and uninfected females are not considered in the development or implementation of control measures. We suggest that this disconnect exists because the link between behavioral alteration and actual transmission in the field has yet to be demonstrated or quantified fully. We review and discuss the current evidence for manipulation, explore its potential significance for malaria transmission, and suggest ways to move this hypothesis forward from theory to potential application in malaria control.
摘要
疟疾寄生虫被认为可以改变蚊子媒介的行为，增加传播的可能性。一些经验证据支持这一假说，但在大多数流行病学模型中忽略了操纵的作用，而且在制定或实施控制措施时也没有考虑感染和未感染雌性之间的行为差异。我们认为这种脱节的存在是因为行为改变与现场实际传播之间的联系尚未得到充分证明或量化。我们回顾和讨论了目前关于操纵的证据，探讨了它对疟疾传播的潜在意义，并提出了将这一假说从理论推进到疟疾控制潜在应用的方法。
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