Joshipura Vaibhavi
Consulting Periodontist, Chinmaya Mission Hospital, Indiranagar, Bangalore, Karnataka, India.
J Indian Soc Periodontol. 2012 Apr;16(2):278-81. doi: 10.4103/0972-124X.99277.
Gingival enlargement is a common clinical feature of gingival and periodontal diseases. Currently, more than 20 prescription medications are associated with gingival enlargement. Although the mechanisms of action may be different, the clinical and microscopic appearance of drug-induced gingival enlargement is similar with any drug. Gingival enlargement produces esthetic changes, and clinical symptoms including pain, tenderness, bleeding, speech disturbances, abnormal tooth movement, dental occlusion problems, enhancement of caries development and periodontal disorders. Sodium valproate is considered to produce gingival enlargement, but very rarely. This case report features sodium valproate induced gingival enlargement in a patient with pre-existing chronic periodontitis, who came to the Dental Department, Chinmaya Mission Hospital, Bangalore. The case is special as the patient did not develop the enlargement in spite of taking phenytoin for 1 year and developed enlargement with sodium valproate within 6 months.
牙龈增生是牙龈疾病和牙周疾病的常见临床特征。目前，超过20种处方药与牙龈增生有关。尽管作用机制可能不同，但药物性牙龈增生的临床和微观表现与任何药物引起的情况相似。牙龈增生会导致美观改变，临床症状包括疼痛、压痛、出血、言语障碍、牙齿异常移动、牙合问题、龋齿发展加速和牙周疾病。丙戊酸钠被认为会导致牙龈增生，但非常罕见。本病例报告描述了一名患有慢性牙周炎的患者，在班加罗尔的Chinmaya Mission医院牙科就诊时，因服用丙戊酸钠导致牙龈增生。该病例较为特殊，因为患者服用苯妥英钠1年未出现增生，而服用丙戊酸钠6个月内就出现了增生。
