University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA 15213, USA.
Curr Diab Rep. 2013 Feb;13(1):63-71. doi: 10.1007/s11892-012-0333-0.
The HEALTHY trial was designed to take a primary prevention approach to risk factors for type 2 diabetes in youth, primarily obesity. The study involved over 6,000 students at 42 middle schools across the U.S. Half received an integrated intervention program of components addressing the school food environment, physical education, lifestyle behaviors, and promotional messaging. The intervention was designed to be more comprehensive than previous efforts, and the research was amply funded. Although the primary objective of reducing the percentage of overweight and obesity in schools that received the intervention program, as compared with control schools, was not obtained, key secondary outcomes indicated an intervention effect. In retrospect, senior investigators involved in the study's design, conduct, and analysis discuss weaknesses and strengths and offer recommendations for future research efforts that address prevention of childhood obesity from a public health perspective.
HEALTHY 试验旨在针对青少年 2 型糖尿病的风险因素（主要是肥胖）采取初级预防措施。该研究涉及美国 42 所中学的 6000 多名学生。其中一半学生接受了一个综合干预计划，该计划涵盖了学校食品环境、体育教育、生活方式行为和宣传信息等方面。该干预计划的设计比以往的努力更加全面，并且得到了充足的资金支持。尽管该研究的主要目标是减少接受干预计划的学校与对照组学校中学生超重和肥胖的比例，但并未达到预期目标，关键次要结果表明干预措施具有效果。回顾研究的设计、实施和分析，参与研究的高级研究人员讨论了研究的弱点和优势，并就从公共卫生角度预防儿童肥胖提供了未来研究工作的建议。
