Nakhaee Alireza, Bokaeian Mohammad, Saravani Mohsen, Farhangi Ali, Akbarzadeh Azim
Department of Biochemistry, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Indian J Clin Biochem. 2009 Oct;24(4):419-25. doi: 10.1007/s12291-009-0075-1. Epub 2009 Dec 30.
In traditional medicine, Eucalyptus globulus (eucalyptus) was used for the treatment of diabetes mellitus. Hyperglycemia in diabetes has been associated with increased formation of reactive oxygen species (ROS) and oxidative damage to tissue compounds. The aim of this study was to evaluate the effects of eucalyptus in the diet (20 g/Kg) and drinking water (2.5 g/L) on lipid peroxidation, protein oxidation and antioxidant power in plasma and liver homogenate, as well as glycated-Hb (HbA(1C)) of blood in streptozotocin-induced diabetic rats for a period of 4 weeks. Diabetes induced in rats by a single intraperitoneal injection of streptozotocin (STZ, 65 mg/Kg). At the end of the treatment period, the level of plasma glucose, plasma and liver malondialdehyde (MDA, the main product of lipid peroxidation), protein carbonyl (PC, one of the protein oxidation products) and HbA(1C) increased and ferric reducing antioxidant power (FRAP) decreased in diabetic rats compared to normal rats. Eucalyptus administration for 4 weeks caused a significant decrease in the plasma glucose levels, plasma and liver MDA, PC and HbA(1C), also a concomitant increase in the levels of FRAP in diabetic treated rats. In conclusion, the present study showed that eucalyptus posses antioxidant activities. Eucalyptus probably restores antioxidant power, due to the improved hyperglycemia in streptozotocin-induced diabetic rats.
在传统医学中，蓝桉（桉树）被用于治疗糖尿病。糖尿病中的高血糖与活性氧（ROS）形成增加以及组织化合物的氧化损伤有关。本研究的目的是评估饮食中（20克/千克）和饮用水中（2.5克/升）的桉树对链脲佐菌素诱导的糖尿病大鼠血浆和肝脏匀浆中的脂质过氧化、蛋白质氧化和抗氧化能力的影响，以及血液中糖化血红蛋白（HbA1C）的影响，为期4周。通过单次腹腔注射链脲佐菌素（STZ，65毫克/千克）诱导大鼠患糖尿病。在治疗期结束时，与正常大鼠相比，糖尿病大鼠的血浆葡萄糖、血浆和肝脏丙二醛（MDA，脂质过氧化的主要产物）、蛋白质羰基（PC，蛋白质氧化产物之一）和HbA1C水平升高，而铁还原抗氧化能力（FRAP）降低。给予桉树4周可使糖尿病大鼠的血浆葡萄糖水平、血浆和肝脏MDA、PC和HbA1C显著降低，同时糖尿病治疗大鼠的FRAP水平也随之升高。总之，本研究表明桉树具有抗氧化活性。由于链脲佐菌素诱导的糖尿病大鼠的高血糖得到改善，桉树可能恢复了抗氧化能力。
