Razmjoo Hasan, Abdi Elham, Atashkadi Sayna, Reza Akhlaghi M, Reza Peyman A, Akbari Mojtaba
Department of Ophtalmology, Isfahan Eye Research Center, Isfahan University of Medical Science, Isfahan, Iran.
Int J Prev Med. 2012 Oct;3(10):718-22.
Silicon hydrogel bandage contact lenses are used to enhance epithelial healing, control surface-generated pain, and prevent epithelial erosions after refractive surgery. Considering the importance of faster reepithelialization in preventing complications of photorefractive keratectomy (PRK) and the fact that the features and specifications of these commercially-available lenses are different and their performance as a postoperative bandage lenses would be different also, the aim of this study was comparison the efficacy of senofilcon A and lotrafilcon A after PRK.
In this prospective study, 44 patients with PRK in both eyes randomly received a silicon hydrogel contact lens of senofilcon A in one eye and lotrafilcon A in other eye. Then the epithelial defect size, visual acuity and subjective level of pain and discomfort were measured for both eyes and compared on day 1, 3 and 5 postoperatively.
There was no statistical difference in rate of reepithelialization between senofilcon A and lotrafilcon A (P > 0.05). The mean pain and discomfort index was significantly lower in eyes with senofilcon A (P < 0.05). The mean subjective visual scores were similar with both bandage contact lenses (BCLs) (P > 0.05).
Silicon hydrogel BCLs are safe and effective for corneal reepithelialization and have great therapeutic outcome on visual outcomes after PRK. But, senofilcon A had better effect on postoperative pain and discomfort which made it superior than lotrafilcon A. However for more conclusive results, it is recommended to study larger sample size with evaluation the possible factors responsible for the obtained findings regarding postoperative pain and discomfort.
硅水凝胶绷带式隐形眼镜用于促进上皮愈合、控制表面产生的疼痛以及预防屈光手术后的上皮糜烂。考虑到在预防准分子激光角膜切削术（PRK）并发症中更快的上皮再形成的重要性，以及这些市售镜片的特性和规格不同且其作为术后绷带式镜片的性能也会不同，本研究的目的是比较PRK术后senofilcon A和lotrafilcon A的疗效。
在这项前瞻性研究中，44例双眼行PRK的患者，一只眼随机接受senofilcon A硅水凝胶隐形眼镜，另一只眼接受lotrafilcon A硅水凝胶隐形眼镜。然后在术后第1天、第3天和第5天测量双眼的上皮缺损大小、视力以及疼痛和不适的主观程度并进行比较。
senofilcon A和lotrafilcon A之间的上皮再形成率无统计学差异（P>0.05）。使用senofilcon A的眼睛的平均疼痛和不适指数显著更低（P<0.05）。两种绷带式隐形眼镜（BCL）的平均主观视觉评分相似（P>0.05）。
硅水凝胶BCL对角膜上皮再形成是安全有效的，并且对PRK后的视觉结果有很好的治疗效果。但是，senofilcon A对术后疼痛和不适有更好的效果，这使其优于lotrafilcon A。然而，为了获得更确凿的结果，建议研究更大的样本量，并评估与术后疼痛和不适相关的可能因素。
