CCR2 在罗西病毒诱导的脑炎中通过促进巨噬细胞浸润到大脑中发挥保护作用。
CCR2 Plays a Protective Role in Rocio Virus-Induced Encephalitis by Promoting Macrophage Infiltration Into the Brain.
机构信息
Laboratory of Virology, Department of Clinical Analyses, Toxicology and Food Sciences, Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil.
Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Australia.
出版信息
J Infect Dis. 2019 May 24;219(12):2015-2025. doi: 10.1093/infdis/jiz029.
Rocio virus (ROCV) is a highly neuropathogenic mosquito-transmitted flavivirus responsible for an unprecedented outbreak of human encephalitis during 1975-1976 in Sao Paulo State, Brazil. Previous studies have shown an increased number of inflammatory macrophages in the central nervous system (CNS) of ROCV-infected mice, implying a role for macrophages in the pathogenesis of ROCV. Here, we show that ROCV infection results in increased expression of CCL2 in the blood and in infiltration of macrophages into the brain. Moreover, we show, using CCR2 knockout mice, that CCR2 expression is essential for macrophage infiltration in the brain during ROCV infection and that the lack of CCR2 results in increased disease severity and mortality. Thus, our findings show the protective role of CCR2-mediated infiltration of macrophages in the brain during ROCV infection.
罗西病毒（ROCV）是一种高度神经致病性的蚊媒传播黄病毒，导致 1975 年至 1976 年在巴西圣保罗州发生了前所未有的人类脑炎爆发。先前的研究表明，ROCV 感染的小鼠中枢神经系统（CNS）中炎症性巨噬细胞数量增加，这意味着巨噬细胞在 ROCV 发病机制中起作用。在这里，我们发现 ROCV 感染导致血液中 CCL2 的表达增加，并导致巨噬细胞浸润到大脑中。此外，我们使用 CCR2 基因敲除小鼠表明，在 ROCV 感染期间，CCR2 的表达对于巨噬细胞浸润到大脑中是必需的，而缺乏 CCR2 会导致疾病严重程度和死亡率增加。因此，我们的研究结果表明，CCR2 介导的巨噬细胞浸润在 ROCV 感染期间对大脑具有保护作用。
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