Department of Hematology, Endocrinology, and Metabolism, Niigata University Faculty of Medicine, 1-757 Asahimachi-dori, Chuoh-ku, Niigata, Japan 951-8510.
J Clin Endocrinol Metab. 2013 Jan;98(1):51-8. doi: 10.1210/jc.2012-2119. Epub 2012 Nov 12.
Recently, several studies have investigated the relationship between diabetes and hearing impairment, but results were inconsistent.
Our objective was to compare the prevalence of hearing impairment between diabetic and nondiabetic adults.
We performed a systematic literature search using MEDLINE (1950 to May 30, 2011) and EMBASE (1974 to May 30, 2011).
Cross-sectional studies were included if data on numbers of hearing-impaired and non-hearing-impaired cases with diabetes were presented. Hearing impairment was limited to that assessed by pure-tone audiometry that included at least 2 kHz of frequency range and was defined as progressive, chronic, sensorineural, or without specified cause.
Two authors independently extracted relevant data. Odd ratios (ORs) of hearing impairment related to diabetes calculated in each study were pooled with the random-effects model.
Data were obtained from 13 eligible studies (20,194 participants and 7,377 cases). Overall pooled OR (95% confidence interval) of hearing impairment for diabetic participants compared with nondiabetic participants was 2.15 (1.72-2.68). OR was higher in younger participants (mean age, ≤60 yr) than in those over 60 yr among which the OR remained significant (2.61 and 1.58, P = 0.008). The strength of the association between diabetes and prevalence of hearing impairment was not significantly influenced by whether participants were matched for age and gender (P = 0.68) or whether participants chronically exposed to noisy environments were excluded (P = 0.19).
Current meta-analysis suggests that the higher prevalence of hearing impairment in diabetic patients compared with nondiabetic patients was consistent regardless of age.
最近，有几项研究调查了糖尿病与听力障碍之间的关系，但结果不一致。
我们的目的是比较糖尿病患者和非糖尿病患者听力障碍的患病率。
我们使用 MEDLINE（1950 年至 2011 年 5 月 30 日）和 EMBASE（1974 年至 2011 年 5 月 30 日）进行了系统的文献检索。
如果有关于糖尿病患者和非糖尿病患者听力受损和非听力受损病例数量的数据，则纳入横断面研究。听力障碍仅限于纯音测听评估，包括至少 2 kHz 的频率范围，并定义为进行性、慢性、感音神经性或无特定原因。
两名作者独立提取相关数据。每个研究中计算的与糖尿病相关的听力障碍的比值比（OR）与随机效应模型一起进行了汇总。
从 13 项合格研究中获得数据（20194 名参与者和 7377 例病例）。与非糖尿病患者相比，糖尿病患者听力障碍的总体汇总 OR（95%置信区间）为 2.15（1.72-2.68）。在年龄≤60 岁的参与者中，OR 高于年龄>60 岁的参与者，其中 OR 仍然显著（2.61 和 1.58，P = 0.008）。糖尿病与听力障碍患病率之间的关联强度不受参与者是否按年龄和性别匹配（P = 0.68）或是否排除长期暴露于嘈杂环境的参与者（P = 0.19）的影响。
目前的荟萃分析表明，与非糖尿病患者相比，糖尿病患者听力障碍的患病率更高，且与年龄无关。
