中年人群冠心病风险特征的变化趋势。
Trends in the coronary heart disease risk profile of middle-aged adults.
机构信息
Aging and Chronic Disease Statistics Branch, Office of Analysis and Epidemiology, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD, USA.
出版信息
Ann Epidemiol. 2013 Jan;23(1):31-4. doi: 10.1016/j.annepidem.2012.10.004. Epub 2012 Nov 22.
PURPOSE
To examine recent trends in the coronary heart disease (CHD) risk profiles of the population aged 45 to 64 in the United States.
METHODS
Data from the National Health and Nutrition Examination Surveys (NHANES) from 2 time periods (1988-1994 and 2005-2008) are used to estimate the CHD risk functions derived from the Framingham Heart Study. The risk functions take account of levels of blood pressure (systolic and diastolic), total and high-density lipoprotein serum cholesterol, diabetes (doctor diagnosed or based on fasting glucose), and smoking status to estimate the 10-year risk of myocardial infarction or coronary death. We estimate the risk functions by gender, race, and age group (45-54 and 55-64).
RESULTS
The CHD risk profile of middle-aged adults has improved over time. For example, the mean 10-year risk of heart attack or CHD death among persons 55 to 64 years has declined from 7.1% to 5.2%. Declines are seen among both men and women and among non-Hispanic Blacks and non-Hispanic whites.
CONCLUSIONS
Despite increases in diabetes and obesity, the CHD risk profile of middle-aged adults improved during the period from 1988-1994 to 2005-2008.
目的
探讨美国 45 至 64 岁人群冠心病（CHD）风险概况的近期趋势。
方法
使用来自两个时期（1988-1994 年和 2005-2008 年）的国家健康和营养检查调查（NHANES）的数据，估算Framingham 心脏研究得出的 CHD 风险函数。这些风险函数考虑了血压（收缩压和舒张压）、总胆固醇和高密度脂蛋白血清胆固醇、糖尿病（医生诊断或基于空腹血糖）和吸烟状况，以估计心肌梗死或冠心病死亡的 10 年风险。我们按性别、种族和年龄组（45-54 岁和 55-64 岁）估算风险函数。
结果
中年成年人的 CHD 风险概况随时间有所改善。例如，55 至 64 岁人群的心脏病发作或 CHD 死亡 10 年风险均值从 7.1%下降到 5.2%。这种下降在男性和女性以及非西班牙裔黑人和非西班牙裔白人中均可见到。
结论
尽管糖尿病和肥胖症有所增加，但在 1988-1994 年至 2005-2008 年期间，中年成年人的 CHD 风险概况有所改善。
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