Drug Quality and Registration (DruQuaR) group, Department of Pharmaceutical Analysis, Faculty of Pharmaceutical Sciences, Ghent Hospital University, Ghent B-9000, Belgium.
Nucleic Acids Res. 2013 Jan;41(Database issue):D655-9. doi: 10.1093/nar/gks1137. Epub 2012 Nov 24.
Quorum-sensing (QS) peptides are biologically attractive molecules, with a wide diversity of structures and prone to modifications altering or presenting new functionalities. Therefore, the Quorumpeps database (http://quorumpeps.ugent.be) is developed to give a structured overview of the QS oligopeptides, describing their microbial origin (species), functionality (method, result and receptor), peptide links and chemical characteristics (3D-structure-derived physicochemical properties). The chemical diversity observed within this group of QS signalling molecules can be used to develop new synthetic bio-active compounds.
群体感应（QS）肽是具有广泛结构多样性且易于修饰的生物活性分子，这些修饰可以改变或呈现新的功能。因此，开发了 Quorumpeps 数据库（http://quorumpeps.ugent.be），以结构化的方式概述 QS 寡肽，描述它们的微生物来源（物种）、功能（方法、结果和受体）、肽链接和化学特性（基于 3D 结构的物理化学性质）。在这组 QS 信号分子中观察到的化学多样性可用于开发新的合成生物活性化合物。
