群体感应肽数据库：化学空间、微生物来源和功能。
Quorumpeps database: chemical space, microbial origin and functionality of quorum sensing peptides.
机构信息
Drug Quality and Registration (DruQuaR) group, Department of Pharmaceutical Analysis, Faculty of Pharmaceutical Sciences, Ghent Hospital University, Ghent B-9000, Belgium.
出版信息
Nucleic Acids Res. 2013 Jan;41(Database issue):D655-9. doi: 10.1093/nar/gks1137. Epub 2012 Nov 24.
Abstract
Quorum-sensing (QS) peptides are biologically attractive molecules, with a wide diversity of structures and prone to modifications altering or presenting new functionalities. Therefore, the Quorumpeps database (http://quorumpeps.ugent.be) is developed to give a structured overview of the QS oligopeptides, describing their microbial origin (species), functionality (method, result and receptor), peptide links and chemical characteristics (3D-structure-derived physicochemical properties). The chemical diversity observed within this group of QS signalling molecules can be used to develop new synthetic bio-active compounds.
摘要
群体感应（QS）肽是具有广泛结构多样性且易于修饰的生物活性分子，这些修饰可以改变或呈现新的功能。因此，开发了 Quorumpeps 数据库（http://quorumpeps.ugent.be），以结构化的方式概述 QS 寡肽，描述它们的微生物来源（物种）、功能（方法、结果和受体）、肽链接和化学特性（基于 3D 结构的物理化学性质）。在这组 QS 信号分子中观察到的化学多样性可用于开发新的合成生物活性化合物。
相似文献
1
Quorumpeps database: chemical space, microbial origin and functionality of quorum sensing peptides.群体感应肽数据库：化学空间、微生物来源和功能。
Nucleic Acids Res. 2013 Jan;41(Database issue):D655-9. doi: 10.1093/nar/gks1137. Epub 2012 Nov 24.
2
Exploring the chemical space of quorum sensing peptides.探索群体感应肽的化学空间。
Biopolymers. 2015 Sep;104(5):544-51. doi: 10.1002/bip.22649.
3
Computational tools for exploring peptide-membrane interactions in gram-positive bacteria.用于探索革兰氏阳性菌中肽-膜相互作用的计算工具。
Comput Struct Biotechnol J. 2023 Mar 2;21:1995-2008. doi: 10.1016/j.csbj.2023.02.051. eCollection 2023.
4
QSIdb: quorum sensing interference molecules.QSIdb：群体感应干扰分子。
Brief Bioinform. 2021 Jul 20;22(4). doi: 10.1093/bib/bbaa218.
5
Identification of Quorum-Sensing Inhibitors Disrupting Signaling between Rgg and Short Hydrophobic Peptides in Streptococci.鉴定破坏链球菌中Rgg与短疏水肽之间信号传导的群体感应抑制剂。
mBio. 2015 May 12;6(3):e00393-15. doi: 10.1128/mBio.00393-15.
6
Quorum sensing inhibitors: a patent overview.群体感应抑制剂：专利概览。
Expert Opin Ther Pat. 2009 Nov;19(11):1581-601. doi: 10.1517/13543770903222293.
7
Structure-function analysis of peptide signaling in the Clostridium perfringens Agr-like quorum sensing system.产气荚膜梭菌Agr样群体感应系统中肽信号的结构-功能分析
J Bacteriol. 2015 May;197(10):1807-18. doi: 10.1128/JB.02614-14. Epub 2015 Mar 16.
8
Development and utilization of peptide-based quorum sensing modulators in Gram-positive bacteria.基于肽的群体感应调节剂在革兰氏阳性菌中的开发和利用。
Org Biomol Chem. 2020 Sep 30;18(37):7273-7290. doi: 10.1039/d0ob01421d.
9
Virtual screening for quorum-sensing inhibitors of Pseudomonas fluorescens P07 from a food-derived compound database.基于食品来源化合物数据库的荧光假单胞菌 P07 群体感应抑制剂的虚拟筛选。
J Appl Microbiol. 2019 Sep;127(3):763-777. doi: 10.1111/jam.14333. Epub 2019 Jun 26.
10
SigMol: repertoire of quorum sensing signaling molecules in prokaryotes.SigMol：原核生物群体感应信号分子库
Nucleic Acids Res. 2016 Jan 4;44(D1):D634-9. doi: 10.1093/nar/gkv1076. Epub 2015 Oct 20.
引用本文的文献
1
IQSPred-PLM: An Interpretable Quorum Sensing Peptides Prediction Model Based on Protein Language Model.IQSPred-PLM：一种基于蛋白质语言模型的可解释群体感应肽预测模型。
Interdiscip Sci. 2025 Aug 26. doi: 10.1007/s12539-025-00766-8.
2
Beyond Molecular Weight: Peptide Characteristics Influencing the Sensitivity of Retention to Changes in Organic Solvent in Reversed-Phase Chromatography.超越分子量：影响反相色谱中保留对有机溶剂变化敏感性的肽段特征
ACS Omega. 2025 Jun 17;10(25):27089-27097. doi: 10.1021/acsomega.5c02327. eCollection 2025 Jul 1.
3
Quorum sensing modulates microbial community structure through regulation of secondary metabolites.群体感应通过调节次生代谢产物来调控微生物群落结构。
mSphere. 2025 Jun 20:e0105024. doi: 10.1128/msphere.01050-24.
4
Molecular structural arrangement in quorum sensing and bacterial metabolic production.群体感应与细菌代谢产物中的分子结构排列
World J Microbiol Biotechnol. 2025 Feb 13;41(2):71. doi: 10.1007/s11274-025-04280-3.
5
Peptipedia v2.0: a peptide sequence database and user-friendly web platform. A major update.Peptipedia v2.0：一个肽序列数据库和用户友好的网络平台。重大更新。
Database (Oxford). 2024 Nov 8;2024. doi: 10.1093/database/baae113.
6
Therapeutic peptides identification via kernel risk sensitive loss-based k-nearest neighbor model and multi-Laplacian regularization.基于核风险敏感损失的 k-最近邻模型和多重拉普拉斯正则化的治疗性肽鉴定。
Brief Bioinform. 2024 Sep 23;25(6). doi: 10.1093/bib/bbae534.
7
BBSdb, an open resource for bacterial biofilm-associated proteins.BBSdb，一个用于细菌生物膜相关蛋白的开放资源。
Front Cell Infect Microbiol. 2024 Aug 1;14:1428784. doi: 10.3389/fcimb.2024.1428784. eCollection 2024.
8
Peptide-based drug discovery through artificial intelligence: towards an autonomous design of therapeutic peptides.基于人工智能的肽类药物发现：迈向治疗性肽的自主设计。
Brief Bioinform. 2024 May 23;25(4). doi: 10.1093/bib/bbae275.
9
Constructions of quorum sensing signaling network for activated sludge microbial community.活性污泥微生物群落群体感应信号网络的构建
ISME Commun. 2024 Jan 27;4(1):ycae018. doi: 10.1093/ismeco/ycae018. eCollection 2024 Jan.
10
Bacterial quorum sensing orchestrates longitudinal interactions to shape microbiota assembly.细菌群体感应协调纵向相互作用，塑造微生物组装配。
Microbiome. 2023 Nov 6;11(1):241. doi: 10.1186/s40168-023-01699-4.
本文引用的文献
1
The potential role of quorum-sensing peptides in oncology.群体感应肽在肿瘤学中的潜在作用。
Med Hypotheses. 2012 Jun;78(6):814-7. doi: 10.1016/j.mehy.2012.03.018. Epub 2012 Apr 16.
2
A strategy for antagonizing quorum sensing.一种对抗群体感应的策略。
Mol Cell. 2011 Apr 22;42(2):199-209. doi: 10.1016/j.molcel.2011.04.003.
3
Involvement of quorum sensing and heat-stable enterotoxin a in cell damage caused by a porcine enterotoxigenic Escherichia coli strain.群体感应和热稳定肠毒素 A 参与猪肠产毒型大肠杆菌引起的细胞损伤。
Infect Immun. 2011 Apr;79(4):1688-95. doi: 10.1128/IAI.01281-10. Epub 2011 Feb 7.
4
Regulation of neurotoxin production and sporulation by a Putative agrBD signaling system in proteolytic Clostridium botulinum.在蛋白水解梭状芽胞杆菌中，一种假定的 AgrBD 信号系统对神经毒素产生和孢子形成的调控作用。
Appl Environ Microbiol. 2010 Jul;76(13):4448-60. doi: 10.1128/AEM.03038-09. Epub 2010 May 7.
5
Metabolic fate of lactoferricin-based antimicrobial peptides: effect of truncation and incorporation of amino acid analogs on the in vitro metabolic stability.基于乳铁蛋白的抗菌肽的代谢命运：截短和氨基酸类似物掺入对体外代谢稳定性的影响。
J Pharmacol Exp Ther. 2010 Mar;332(3):1032-9. doi: 10.1124/jpet.109.162826. Epub 2009 Dec 1.
6
Microbial growth and quorum sensing antagonist activities of herbal plants extracts.草药提取物的微生物生长及群体感应拮抗活性
Molecules. 2009 Sep 3;14(9):3425-35. doi: 10.3390/molecules14093425.
7
Antimicrobial effect of farnesol, a Candida albicans quorum sensing molecule, on Paracoccidioides brasiliensis growth and morphogenesis.法尼醇（一种白色念珠菌群体感应分子）对巴西副球孢子菌生长和形态发生的抗菌作用。
Ann Clin Microbiol Antimicrob. 2009 Apr 29;8:13. doi: 10.1186/1476-0711-8-13.
8
Complexity in bacterial cell-cell communication: quorum signal integration and subpopulation signaling in the Bacillus subtilis phosphorelay.细菌细胞间通讯的复杂性：枯草芽孢杆菌磷酸化信号转导中的群体感应信号整合与亚群体信号传导
Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6459-64. doi: 10.1073/pnas.0810878106. Epub 2009 Apr 20.
9
Peptides for tumour therapy and diagnosis: current status and future directions.用于肿瘤治疗和诊断的肽：现状与未来方向。
Curr Med Chem. 2009;16(7):780-95. doi: 10.2174/092986709787549307.
10
Effects of quorum sensing on cell viability in Streptococcus mutans biofilm formation.群体感应对变形链球菌生物膜形成中细胞活力的影响。
Biochem Biophys Res Commun. 2009 Feb 20;379(4):933-8. doi: 10.1016/j.bbrc.2008.12.175. Epub 2009 Jan 10.
Zotero 插件