从冲绳软珊瑚 Cespitularia sp. 中分离得到的 5 个新二萜
Five new diterpenoids from an Okinawan soft coral, Cespitularia sp.
机构信息
Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara-cho, Okinawa 903-2013, Japan.
出版信息
Mar Drugs. 2012 Nov 30;10(12):2741-8. doi: 10.3390/md10122741.
Five new diterpenoids 1-5 were isolated from an Okinawan soft coral, Cespitularia sp., together with the known diterpenoid, alcyonolide (6). New diterpenoid structures were elucidated by spectroscopic methods and by comparison of their NMR data with those of related compounds. Alcyonolide (6) was cytotoxic against HCT 116 cells (IC₅₀ 5.85 μM), while these new diterpenoids 1-5 were much less active (IC₅₀ 28.2-91.4 μM).
从冲绳软珊瑚 Cespitularia sp. 中分离得到 5 个新二萜 1-5，以及已知的二萜醇内酯 6。通过光谱方法和与相关化合物的 NMR 数据比较，阐明了新二萜的结构。二萜醇内酯 6 对 HCT 116 细胞具有细胞毒性（IC₅₀ 5.85 μM），而这些新二萜 1-5 的活性则低得多（IC₅₀ 28.2-91.4 μM）。
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