Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603 203, TamilNadu, India.
Int J Biol Macromol. 2013 Mar;54:24-9. doi: 10.1016/j.ijbiomac.2012.11.026. Epub 2012 Nov 29.
Hydrogels are hydrophilic polymers that have a wide range of biomedical applications including bone tissue engineering. In this study we report preparation and characterization of a thermosensitive hydrogel (Zn-CS/β-GP) containing zinc (Zn), chitosan (CS) and beta-glycerophosphate (β-GP) for bone tissue engineering. The prepared hydrogel exhibited a liquid state at room temperature and turned into a gel at body temperature. The hydrogel was characterized by SEM, EDX, XRD, FT-IR and swelling studies. The hydrogel enhanced antibacterial activity and promoted osteoblast differentiation. Thus, we suggest that the Zn-CS/β-GP hydrogel could have potential impact as an injectable in situ forming scaffold for bone tissue engineering applications.
水凝胶是一种亲水性聚合物，具有广泛的生物医学应用，包括骨组织工程。在这项研究中，我们报告了一种含锌（Zn）、壳聚糖（CS）和β-甘油磷酸（β-GP）的温敏水凝胶（Zn-CS/β-GP）的制备和表征，用于骨组织工程。所制备的水凝胶在室温下呈液态，在体温下变成凝胶。通过 SEM、EDX、XRD、FT-IR 和溶胀研究对水凝胶进行了表征。水凝胶增强了抗菌活性并促进成骨细胞分化。因此，我们认为 Zn-CS/β-GP 水凝胶有望作为一种可注射的原位形成支架，用于骨组织工程应用。
