Integrated Research Facility, Division of Clinical Research, NIAID, NIH, Frederick, MD, USA.
Viruses. 2012 Oct 23;4(10):2400-16. doi: 10.3390/v4102400.
Baboons are susceptible to natural Ebola virus (EBOV) infection and share 96% genetic homology with humans. Despite these characteristics, baboons have rarely been utilized as experimental models of human EBOV infection to evaluate the efficacy of prophylactics and therapeutics in the United States. This review will summarize what is known about the pathogenesis of EBOV infection in baboons compared to EBOV infection in humans and other Old World nonhuman primates. In addition, we will discuss how closely the baboon model recapitulates human EBOV infection. We will also review some of the housing requirements and behavioral attributes of baboons compared to other Old World nonhuman primates. Due to the lack of data available on the pathogenesis of Marburg virus (MARV) infection in baboons, discussion of the pathogenesis of MARV infection in baboons will be limited.
食蟹猴容易感染天然埃博拉病毒(EBOV),与人类的基因同源性达 96%。尽管具有这些特点,但食蟹猴在美国很少被用作人类 EBOV 感染的实验模型,以评估预防和治疗药物的疗效。本文将综述食蟹猴 EBOV 感染的发病机制与人类及其他旧大陆非人灵长类动物 EBOV 感染的异同,并讨论食蟹猴模型与人 EBOV 感染的吻合程度。此外,我们还将比较食蟹猴与其他旧大陆非人灵长类动物的饲养要求和行为特征。由于缺乏有关食蟹猴马尔堡病毒(MARV)感染发病机制的数据,本文将仅限于讨论食蟹猴 MARV 感染的发病机制。