Loy V, Wigand I, Dieckmann K P
Institute of Pathology, Universitätsklinikum Steglitz, Free University of Berlin, FRG.
Histopathology. 1990 Feb;16(2):198-200. doi: 10.1111/j.1365-2559.1990.tb01093.x.
A total of 127 testicular specimens with germ cell tumours were stained immunohistologically for placental alkaline phosphatase to investigate the presence and topographic distribution of carcinoma in situ cells adjacent to the invasive tumours. Carcinoma in situ was detected in 72% of the cases. In 60% of the cases positive for placental alkaline phosphatase the distribution of carcinoma in situ was not diffuse, as claimed in the literature, but focal. Clinicians screening for carcinoma in situ by only one random biopsy have, therefore, to be aware of possible false negative results.
对127例患有生殖细胞肿瘤的睾丸标本进行胎盘碱性磷酸酶免疫组织化学染色，以研究侵袭性肿瘤旁原位癌细胞的存在及拓扑分布。72%的病例检测到原位癌。在60%胎盘碱性磷酸酶呈阳性的病例中，原位癌的分布并非如文献中所述为弥漫性，而是局灶性的。因此，仅通过一次随机活检筛查原位癌的临床医生必须意识到可能出现假阴性结果。
