Loyha Kulchaya, Vatanasapt Patravoot, Promthet Supannee, Parkin Donald Maxwell
Department of Epidemiology, Faculty of Public Health, Khon Kaen University, Thailand.
Asian Pac J Cancer Prev. 2012;13(10):5087-90. doi: 10.7314/apjcp.2012.13.10.5087.
Oral cancer is a common site of head and neck cancer, and is relatively frequent in Northeast Thailand. The objective of this hospital-based, case-control study was to determine associations with risk factors. A total of 104 oral cancer cases diagnosed between July 2010 and April 2011 in 3 hospitals were matched with control subjects by age, sex and hospital. Data were collected by personal interview. There were significant associations between oral cancer and tobacco smoking (OR=4.47; 95%CI=2.00 to 9.99), alcohol use among women (OR=4.16; 95%CI=1.70 to 10.69), and betel chewing (OR=9.01; 95%CI=3.83 to 21.22), and all three showed dose-response effects. Smoking is rare among Thai women (none of the control women were smokers), but betel chewing, especially among older women, is relatively common. We did not find any association between practicing oral sex and oral cancer.
口腔癌是头颈癌的常见发病部位，在泰国东北部较为频发。这项基于医院的病例对照研究旨在确定其与风险因素之间的关联。2010年7月至2011年4月期间，在3家医院诊断出的104例口腔癌病例，按照年龄、性别和医院与对照对象进行匹配。通过个人访谈收集数据。口腔癌与吸烟（比值比=4.47；95%置信区间=2.00至9.99）、女性饮酒（比值比=4.16；95%置信区间=1.70至10.69）以及嚼槟榔（比值比=9.01；95%置信区间=3.83至21.22）之间存在显著关联，且这三者均呈现剂量反应效应。吸烟在泰国女性中很少见（对照女性中无吸烟者），但嚼槟榔，尤其是在老年女性中相对普遍。我们未发现口交与口腔癌之间存在任何关联。
