New York Obesity Nutrition Research Center, Department of Medicine, St Luke's-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Int J Obes (Lond). 2013 Aug;37(8):1104-8. doi: 10.1038/ijo.2012.166. Epub 2012 Dec 18.
To explore appetite-related hormones following stress in overweight individuals, and their relationship with night eating (NE) status.
We measured plasma cortisol and ghrelin concentrations, and recorded ratings of stress and hunger in response to a physiological laboratory stressor (cold pressor test, CPT), in overweight women with (n=11; NE) and without (n=17; non-NE) NE.
Following the CPT, cortisol (P<0.001) and ghrelin (P<0.05) levels increased, as did stress and hunger ratings (all P<0.001), across all subjects (NE and non-NE). NE exhibited higher baseline cortisol (P<0.05) levels than non-NE. NE also had greater cortisol area under the curve (AUC) than non-NE (P=0.019), but not when controlling for baseline cortisol levels. Ghrelin baseline and AUC did not differ between groups. NE showed higher AUC stress (P<0.05), even when controlling for baseline stress.
Overweight individuals showed increased cortisol, ghrelin, stress and hunger following a laboratory stressor, and there was some evidence for greater increases in cortisol and subjective stress among NE. The greater AUC cortisol level in NE was due to higher baseline levels, but the group difference in stress was in direct response to the stressor. Our results support a role for cortisol and stress in NE.
探讨超重个体应激后与食欲相关的激素变化及其与夜间进食（NE）状态的关系。
我们测量了血浆皮质醇和胃饥饿素浓度，并记录了超重女性（NE 组，n=11；非 NE 组，n=17）在生理实验室应激源（冷水压迫试验，CPT）刺激下的应激和饥饿感评分。
CPT 后，所有受试者（NE 和非 NE）的皮质醇（P<0.001）和胃饥饿素（P<0.05）水平升高，应激和饥饿感评分均升高（均 P<0.001）。NE 组的基线皮质醇水平高于非 NE 组（P<0.05）。NE 组的皮质醇曲线下面积（AUC）也高于非 NE 组（P=0.019），但未校正基线皮质醇水平。两组间胃饥饿素的基线和 AUC 无差异。即使校正了基线应激，NE 组的 AUC 应激也更高（P<0.05）。
超重个体在接受实验室应激源后皮质醇、胃饥饿素、应激和饥饿感均增加，NE 者的皮质醇和主观应激增加更为明显。NE 者皮质醇 AUC 水平较高的原因是基线水平较高，但应激组间的差异是对应激源的直接反应。我们的结果支持皮质醇和应激在 NE 中的作用。
