Thavarajah Rooban, Mudimbaimannar Vidya Kazhiyur, Elizabeth Joshua, Rao Umadevi Krishnamohan, Ranganathan Kannan
Department of OralandMaxillofacial Pathology, Ragas Dental College and Hospital, Uthandi, Chennai, India.
J Oral Maxillofac Pathol. 2012 Sep;16(3):400-5. doi: 10.4103/0973-029X.102496.
Formaldehyde is the widely employed fixative that has been studied for decades. The chemistry of fixation has been studied widely since the early 20(th) century. However, very few studies have been focused on the actual physics/chemistry aspect of process of this fixation. This article attempts to explain the chemistry of formaldehyde fixation and also to study the physical aspects involved in the fixation. The factors involved in the fixation process are discussed using well documented mathematical and physical formulae. The deeper understanding of these factors will enable pathologist to optimize the factors and use them in their favor.
甲醛是一种被广泛使用的固定剂，几十年来一直受到研究。自20世纪初以来，固定化学就得到了广泛研究。然而，很少有研究聚焦于这种固定过程实际的物理/化学方面。本文试图解释甲醛固定的化学原理，并研究固定过程中涉及的物理方面。使用有充分文献记载的数学和物理公式来讨论固定过程中涉及的因素。对这些因素的更深入理解将使病理学家能够优化这些因素并使其有利于自身工作。
