Gendrel D, Dupont C, Richard-Lenoble D, Gendrel C, Chaussain M
Centre Universitaire des Sciences de la Santé, Libreville, Gabon, France.
J Pediatr Gastroenterol Nutr. 1990 Jan;10(1):44-6. doi: 10.1097/00005176-199001000-00009.
Fresh yogurt has been proposed as a milk substitute for lactase-deficient patients. We investigated the possibility that a dried, low-fat milk fermented by yogurt microorganisms would be effective. Processing of a fermented milk by spray-drying led to a powder with persistence of lactase activity (11.7 units/g) without storage at 4 degrees C and stable at room temperature (20-23 degrees C). The tolerance and absorption of 10.5 g of lactose in a volume of 150 ml was studied in 25 Gabonese lactase-deficient children aged 5-14 years in the form of a standard humanized milk formula followed 1 week later by the powdered fermented milk formula. Results of the breath hydrogen test showed that in 24 of 25 cases, lactose absorption was normal with a maximal rise of hydrogen over baseline of under 13 ppm after ingestion of the powdered fermented milk. The rise was above 20 ppm in the 25 children with the same load of lactose in the form of the standard formula and one-third had symptoms of lactose intolerance. This powdered fermented milk preparation should be considered as a valid approach in programs of nutritional support targeted to countries with a high prevalence of lactase deficiency.
新鲜酸奶已被提议作为乳糖酶缺乏患者的牛奶替代品。我们研究了用酸奶微生物发酵的低脂奶粉是否有效的可能性。通过喷雾干燥处理发酵乳得到一种粉末，其乳糖酶活性得以保留（11.7单位/克），无需在4℃下储存且在室温（20 - 23℃）下稳定。以标准配方奶粉形式给25名5至14岁的加蓬乳糖酶缺乏儿童服用150毫升含10.5克乳糖的奶粉，1周后再服用这种发酵奶粉。呼气氢试验结果表明，25例中有24例在摄入发酵奶粉后乳糖吸收正常，呼出氢气量较基线的最大增加值低于13 ppm。以标准配方奶粉形式摄入相同乳糖量时，25名儿童呼出氢气量增加值高于20 ppm，三分之一的儿童有乳糖不耐受症状。这种发酵奶粉制剂应被视为针对乳糖酶缺乏高患病率国家的营养支持项目中的一种有效方法。
