van de Heijning Bert J M, Berton Amelie, Bouritius Hetty, Goulet Olivier
Nutricia Research, Early Life Nutrition, P.O. Box 80141, 3508 TC Utrecht, The Netherlands.
Department of Pediatric Gastroenterology-Hepatology and Nutrition, Necker Children's Hospital, University of Paris, 75015 Paris, France.
Nutrients. 2014 Sep 25;6(9):3942-67. doi: 10.3390/nu6093942.
Besides pre- and pro-biotic-containing infant formulae, fermented infant formulae are commonly used to relieve or prevent symptoms of gastrointestinal (GI) discomfort in young infants. During the fermentation process in cow's milk-based formulae, the beneficial bacteria modulate the product by forming several beneficial compounds, which contribute to the alleviation of the symptoms observed. This review summarizes the clinical evidence on the impact of fermented infant formulae on common pediatric GI-symptoms. The potential mechanisms involved are discussed: i.e., the lactose and protein (in-) digestibility, effects on gastric emptying and gut transit and modulation of the colonic microbiota. Although initial evidence indicates a beneficial effect of fermented formulae on GI discomfort in newborns, validation and confirmation of the clinical proof obtained so far is warranted, as well as further research to (more fully) understand the mode of action.
除了含有益生菌和益生元的婴儿配方奶粉外，发酵型婴儿配方奶粉通常用于缓解或预防幼儿胃肠道（GI）不适症状。在以牛奶为基础的配方奶粉发酵过程中，有益细菌通过形成几种有益化合物来调节产品，这些化合物有助于缓解所观察到的症状。本综述总结了关于发酵型婴儿配方奶粉对常见儿科胃肠道症状影响的临床证据。文中讨论了其中涉及的潜在机制，即乳糖和蛋白质的（不）消化性、对胃排空和肠道转运的影响以及对结肠微生物群的调节。尽管初步证据表明发酵型配方奶粉对新生儿胃肠道不适有有益作用，但仍需对目前获得的临床证据进行验证和确认，以及进行进一步研究以（更全面地）了解其作用方式。
