FOM Institute AMOLF, Science Park 104, 1098 XG Amsterdam, The Netherlands.
Curr Opin Cell Biol. 2013 Feb;25(1):23-9. doi: 10.1016/j.ceb.2012.12.002. Epub 2013 Jan 1.
Microtubules organize into a set of distinct patterns with the help of associated molecules that control nucleation, polymerization, crosslinking, and transport. These patterns, alone or in combination with each other, define the functional architecture of the microtubule cytoskeleton in living cells. In vitro experiments of increasing complexity help understand, in combination with theoretical models, the basic mechanisms by which elementary microtubule patterns arise, how they are maintained, and how they position themselves with respect to the confining geometry of living cells.
微管在相关分子的帮助下组织成一组独特的模式，这些分子控制着成核、聚合、交联和运输。这些模式，单独或相互结合，定义了活细胞中微管细胞骨架的功能结构。越来越复杂的体外实验有助于结合理论模型理解基本的微管模式形成机制、它们如何维持以及它们如何相对于活细胞的限制几何形状定位。
