Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Invest Ophthalmol Vis Sci. 2012 Mar 1;53(3):1102-7. doi: 10.1167/iovs.11-8836.
To compare subfoveal choroidal thickness (SCT) measurements of three different commercially available spectral-domain optical coherence tomography instruments with healthy eyes of Japanese.
A prospective, cross-sectional study was performed at a single institution. SCT of the right eye of 43 normal subjects was measured using three different SD-OCTs: Heidelberg Spectralis-OCT (Spectralis), Cirrus HD-OCT (Cirrus), and Topcon 3D OCT-1000 Mark II (Topcon). Two separate measurements were performed for the same eye with a maximum by a single examiner. SCT was defined as the distance from the posterior edge of the retinal pigment epithelium to the choroid/sclera junction. After manual segmentation, measurements were made using calipers equipped on each machine by masked raters. Intraclass, interrater, and intermachine agreements were assessed.
Forty-three subjects (mean age, 30.5 years) were enrolled. Of 43 eyes, the SCT of 39 eyes (90.7%) could be measured using each machine. Intraclass correlation coefficients (95% confidence intervals) were 0.976 (0.954-9.987), 0.958 (0.919-0.978), and 0.939 (0.895-0.971) with Spectralis, Cirrus, and Topcon, respectively. Interrater correlation coefficients (95% confident interval) were 0.944 (0.893 to 0.971), 0.956 (0.831 to 0.983), and 0.924 (0.825 to 0.964) with Spectralis, Cirrus, and Topcon, respectively. The average SCT was 272.6, 272.8, and 269.2 μm with Spectralis, Cirrus, and Topcon, respectively. The intermachine correlation coefficient was significantly high among the machines (P<0.001, Spearman), 0.97 (Spectralis-Cirrus), 0.96 (Cirrus-Topcon), and 0.98 (Topcon-Cirrus). Bland-Altman plot analysis showed no typical trend among the machines.
SCT measurements obtained with three different SD-OCTs were highly correlated and could be used interchangeably. (http://upload.umin.ac.jp number, UMIN000005287.).
比较三种不同商用谱域光学相干断层扫描（SD-OCT）仪器在日本健康人眼中的黄斑中心凹下脉络膜厚度（SCT）测量值。
在单中心进行前瞻性、横断面研究。对 43 例右眼进行 SCT 测量，使用三种不同的 SD-OCT：海德堡 Spectralis-OCT（Spectralis）、Cirrus HD-OCT（Cirrus）和 Topcon 3D OCT-1000 Mark II（Topcon）。同一只眼由一名检查者进行两次最大测量。SCT 定义为视网膜色素上皮后缘至脉络膜/巩膜交界处的距离。手动分割后，使用每台机器配备的卡尺进行测量，由盲法评估者进行。评估了组内、组间和组间的一致性。
纳入 43 例（平均年龄 30.5 岁）受试者。43 只眼中，39 只眼（90.7%）可使用每种机器进行 SCT 测量。Spectralis、Cirrus 和 Topcon 的组内相关系数（95%置信区间）分别为 0.976（0.954-9.987）、0.958（0.919-0.978）和 0.939（0.895-0.971）。Spectralis、Cirrus 和 Topcon 的组间相关系数（95%置信区间）分别为 0.944（0.893 至 0.971）、0.956（0.831 至 0.983）和 0.924（0.825 至 0.964）。Spectralis、Cirrus 和 Topcon 的平均 SCT 分别为 272.6、272.8 和 269.2μm。各仪器间的组间相关性系数（Spearman）非常高，分别为 0.97（Spectralis-Cirrus）、0.96（Cirrus-Topcon）和 0.98（Topcon-Cirrus）。Bland-Altman 图分析显示各仪器之间没有典型趋势。
三种不同的 SD-OCT 获得的 SCT 测量值高度相关，可相互替换使用。（http://upload.umin.ac.jp number，UMIN000005287.）。
