Dental School, University of Insubria, Varese, Italy.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Jun;115(6):717-23. doi: 10.1016/j.oooo.2012.09.087. Epub 2013 Jan 10.
Mesenchymal stem cells (MSCs) have been applied in maxillary sinus augmentation (MSA) with clinically successful results. The purpose of this article was to evaluate the systematically acquired evidence for the effectiveness of cell-based approaches in MSA with various scaffolds, and to narratively assess evidence from additional articles that report effectiveness of cell-based approaches in MSA.
Electronic database searches were performed. Inclusion criteria were studies of cell-based approaches in MSA with various scaffolds, in humans, with at least 3 to 4 months of follow-up. Meta-analysis was performed for randomized controlled trials (RCTs) with histologic/histomorphometric evaluation.
Fifteen studies (4 RCTs) were considered to be eligible for inclusion in the review. The meta-analysis suggested a marginal, nonstatistically significant positive effect of MSCs on the bone regrowth.
A number of studies have demonstrated the potential for cell-based approaches in MSA; further RCTs that clearly demonstrate benefits of cell-based approach are needed.
间充质干细胞（MSCs）已被应用于上颌窦提升（MSA）中，并取得了临床成功的结果。本文旨在评估各种支架的基于细胞的方法在 MSA 中有效性的系统获取证据，并从报告 MSA 中基于细胞的方法有效性的其他文章中进行叙述性评估。
进行电子数据库检索。纳入标准为使用各种支架的基于细胞的方法治疗 MSA 的研究，研究对象为人类，随访时间至少为 3 至 4 个月。对具有组织学/组织形态计量学评估的随机对照试验（RCT）进行荟萃分析。
有 15 项研究（4 项 RCT）被认为符合纳入综述的标准。荟萃分析表明，MSCs 对骨再生有一定的、非统计学上显著的积极影响。
许多研究已经证明了基于细胞的方法在 MSA 中的潜力；需要进一步的 RCT 来明确证明基于细胞的方法的益处。
