University of Wisconsin, Madison, Wisconsin, USA.
Antimicrob Agents Chemother. 2013 Apr;57(4):1918-20. doi: 10.1128/AAC.02378-12. Epub 2013 Jan 14.
Candida biofilm infections pose an increasing threat in the health care setting due to the drug resistance associated with this lifestyle. Several mechanisms underlie the resistance phenomenon. In Candida albicans, one mechanism involves drug impedance by the biofilm matrix linked to β-1,3 glucan. Here, we show this is important for other Candida spp. We identified β-1,3 glucan in the matrix, found that the matrix sequesters antifungal drug, and enhanced antifungal susceptibility with matrix β-1,3 glucan hydrolysis.
由于与这种生活方式相关的耐药性，假丝酵母菌生物膜感染在医疗环境中构成的威胁日益增加。耐药现象有几个潜在机制。在白假丝酵母菌中，一个机制涉及与β-1,3 葡聚糖相关的生物膜基质对药物的阻抗。在这里，我们表明这对于其他假丝酵母菌种也很重要。我们在基质中鉴定出β-1,3 葡聚糖，发现基质隔离了抗真菌药物，并通过基质β-1,3 葡聚糖水解增强了抗真菌药物的敏感性。
