奇异变形杆菌中发现的新型 CTX-M-116 β-内酰胺酶基因由 CTX-M-22 和 CTX-M-23 基因的部分组成。
The novel CTX-M-116 β-lactamase gene discovered in Proteus mirabilis is composed of parts of the CTX-M-22 and CTX-M-23 genes.
机构信息
The State Research Center for Applied Microbiology & Biotechnology, Obolensk, Russia.
出版信息
Antimicrob Agents Chemother. 2013 Mar;57(3):1552-5. doi: 10.1128/AAC.01471-12. Epub 2013 Jan 14.
Abstract
The novel β-lactamase gene bla(CTX-M-116) was identified in a Proteus mirabilis nosocomial isolate recovered from the urine of a patient in Moscow in 2005. DNA sequence analysis showed bla(CTX-M-116) to be a hybrid gene consisting of 5' bla(CTX-M-23) (nucleotides 1 to 278) and 3' bla(CTX-M-22) (nucleotides 286 to 876) moieties separated by an intervening putative site of recombination (GTTAAAT). A retrospective analysis of available bla(CTX-M) genes in the GenBank database revealed 19 bla(CTX-M) genes that display the same hybrid structure.
摘要
2005 年，从莫斯科一位患者的尿液中分离出的奇异变形杆菌临床分离株中发现了新型β-内酰胺酶基因 bla(CTX-M-116)。DNA 序列分析表明，bla(CTX-M-116)是一种杂合基因，由 5'bla(CTX-M-23)(核苷酸 1 至 278)和 3'bla(CTX-M-22)(核苷酸 286 至 876)两部分组成，中间有一个推测的重组位点(GTTAAAT)。对 GenBank 数据库中现有 bla(CTX-M)基因的回顾性分析显示，有 19 个 bla(CTX-M)基因显示出相同的杂合结构。
相似文献
1
The novel CTX-M-116 β-lactamase gene discovered in Proteus mirabilis is composed of parts of the CTX-M-22 and CTX-M-23 genes.奇异变形杆菌中发现的新型 CTX-M-116 β-内酰胺酶基因由 CTX-M-22 和 CTX-M-23 基因的部分组成。
Antimicrob Agents Chemother. 2013 Mar;57(3):1552-5. doi: 10.1128/AAC.01471-12. Epub 2013 Jan 14.
2
Interspecies spread of CTX-M-32 extended-spectrum beta-lactamase and the role of the insertion sequence IS1 in down-regulating bla CTX-M gene expression.CTX-M-32 超广谱β-内酰胺酶的种间传播以及插入序列IS1在下调 bla CTX-M 基因表达中的作用。
J Antimicrob Chemother. 2007 May;59(5):841-7. doi: 10.1093/jac/dkm030. Epub 2007 Mar 1.
3
Nosocomial outbreak by Proteus mirabilis producing extended-spectrum beta-lactamase VEB-1 in a Korean university hospital.韩国一家大学医院中奇异变形杆菌产生超广谱β-内酰胺酶VEB-1导致的医院感染暴发。
J Antimicrob Chemother. 2004 Dec;54(6):1144-7. doi: 10.1093/jac/dkh486. Epub 2004 Nov 16.
4
Emergence of Proteus mirabilis carrying the bla metallo-beta-lactamase gene.携带bla金属β-内酰胺酶基因的奇异变形杆菌的出现。
Clin Microbiol Infect. 2006 Jul;12(7):691-4. doi: 10.1111/j.1469-0691.2006.01489.x.
5
The first detection of CTX-M-14 extended-spectrum beta-lactamase among diverse beta-lactamase-producing Proteus mirabilis clinical isolates.在多种产β-内酰胺酶的奇异变形杆菌临床分离株中首次检测到CTX-M-14超广谱β-内酰胺酶
Diagn Microbiol Infect Dis. 2006 Mar;54(3):237-9. doi: 10.1016/j.diagmicrobio.2005.09.013. Epub 2006 Jan 19.
6
Dissemination of Proteus mirabilis isolates harboring CTX-M-14 and CTX-M-3 beta-lactamases at 2 hospitals in Taiwan.台湾两家医院中携带CTX-M-14和CTX-M-3β-内酰胺酶的奇异变形杆菌分离株的传播情况。
Diagn Microbiol Infect Dis. 2006 Feb;54(2):89-94. doi: 10.1016/j.diagmicrobio.2005.09.005. Epub 2006 Jan 9.
7
CTX-M-1 extended-spectrum beta-lactamase-producing Proteus mirabilis in Greece.希腊产CTX-M-1型超广谱β-内酰胺酶的奇异变形杆菌
Microb Drug Resist. 2005 Winter;11(4):351-4. doi: 10.1089/mdr.2005.11.351.
8
High prevalence of CTX-M-15 and first report of CTX-M-3, CTX-M-22, CTX-M-28 and plasmid-mediated AmpC beta-lactamase producing Enterobacteriaceae causing urinary tract infections in Bosnia and Herzegovina in hospital and community settings.CTX-M-15的高流行率以及CTX-M-3、CTX-M-22、CTX-M-28和质粒介导的AmpCβ-内酰胺酶产生肠杆菌科细菌在波斯尼亚和黑塞哥维那医院和社区环境中引起尿路感染的首次报告。
J Infect Chemother. 2015 May;21(5):363-9. doi: 10.1016/j.jiac.2015.01.003. Epub 2015 Jan 9.
9
Rapidly spreading CTX-M-type beta-lactamase-producing Proteus mirabilis in Japan.日本迅速传播的产 CTX-M 型超广谱β-内酰胺酶奇异变形杆菌。
Int J Antimicrob Agents. 2010 Oct;36(4):340-2. doi: 10.1016/j.ijantimicag.2010.06.002. Epub 2010 Jul 7.
10
Chromosome-encoded AmpC and CTX-M extended-spectrum β-lactamases in clinical isolates of Proteus mirabilis from Korea.韩国奇异变形杆菌临床分离株中染色体编码的 AmpC 和 CTX-M 型超广谱β-内酰胺酶。
Antimicrob Agents Chemother. 2011 Apr;55(4):1414-9. doi: 10.1128/AAC.01835-09. Epub 2011 Jan 31.
引用本文的文献
1
Endolysins of bacteriophage vB_Sal-S-S10 can naturally lyse Salmonella enteritidis.噬菌体 vB_Sal-S-S10 的内溶素可以自然裂解肠炎沙门氏菌。
BMC Vet Res. 2022 Nov 21;18(1):410. doi: 10.1186/s12917-022-03514-y.
2
Reply to "Generation of the blaCTX-M-116 hybrid gene".对《blaCTX-M-116杂交基因的产生》的回复
Antimicrob Agents Chemother. 2013 Aug;57(8):4092. doi: 10.1128/AAC.00743-13.
3
Generation of the blaCTX-M-116 hybrid gene.blaCTX-M-116杂合基因的产生。
Antimicrob Agents Chemother. 2013 Aug;57(8):4091. doi: 10.1128/AAC.00673-13.
本文引用的文献
1
2
Epidemiological expansion, structural studies, and clinical challenges of new β-lactamases from gram-negative bacteria.革兰氏阴性菌新型β-内酰胺酶的流行病学扩张、结构研究和临床挑战。
Annu Rev Microbiol. 2011;65:455-78. doi: 10.1146/annurev-micro-090110-102911.
3
High prevalence of bla(CTX-M) extended-spectrum β-lactamase genes in Escherichia coli isolates from pets and emergence of CTX-M-64 in China.宠物源大肠杆菌中 bla(CTX-M) 型超广谱β-内酰胺酶基因的高流行率及 CTX-M-64 在我国的出现。
Clin Microbiol Infect. 2010 Sep;16(9):1475-81. doi: 10.1111/j.1469-0691.2010.03127.x.
4
5
Analysis of antibiotic resistance regions in Gram-negative bacteria.革兰氏阴性菌耐药区域分析。
FEMS Microbiol Rev. 2011 Sep;35(5):820-55. doi: 10.1111/j.1574-6976.2011.00277.x. Epub 2011 Jun 16.
6
7
Resistance to cephalosporins and carbapenems in Gram-negative bacterial pathogens.革兰氏阴性细菌病原体对头孢菌素类和碳青霉烯类的耐药性。
Int J Med Microbiol. 2010 Aug;300(6):371-9. doi: 10.1016/j.ijmm.2010.04.005. Epub 2010 May 27.
8
Evolutionary trajectories of beta-lactamase CTX-M-1 cluster enzymes: predicting antibiotic resistance.CTX-M-1 型β-内酰胺酶簇酶的进化轨迹：预测抗生素耐药性。
PLoS Pathog. 2010 Jan 22;6(1):e1000735. doi: 10.1371/journal.ppat.1000735.
9
Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime.新型嵌合β-内酰胺酶CTX-M-64，是CTX-M-15样和CTX-M-14β-内酰胺酶的杂交体，在一株对包括头孢他啶在内的多种氧亚氨基头孢菌素耐药的宋内志贺菌菌株中发现。
Antimicrob Agents Chemother. 2009 Jan;53(1):69-74. doi: 10.1128/AAC.00227-08. Epub 2008 Oct 27.
10
Prevalence of rectal carriage of extended-spectrum beta-lactamase-producing Escherichia coli among elderly people in community settings in China.中国社区老年人中产超广谱β-内酰胺酶大肠埃希菌直肠携带情况
Can J Microbiol. 2008 Sep;54(9):781-5. doi: 10.1139/w08-059.
Zotero 插件