Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Dev Cell. 2013 Jan 14;24(1):1-12. doi: 10.1016/j.devcel.2012.11.020.
A major challenge in nuclear organization is the packaging of DNA into dynamic chromatin structures that can respond to changes in the transcriptional requirements of the cell. Posttranslational protein modifications, of histones and other chromatin-associated factors, are essential regulators of chromatin dynamics. In this Review, we summarize studies demonstrating that posttranslational modification of proteins by small ubiquitin-related modifiers (SUMOs) regulates chromatin structure and function at multiple levels and through a variety of mechanisms to influence gene expression and maintain genome integrity.
核组织的一个主要挑战是将 DNA 包装成动态的染色质结构，以响应细胞转录需求的变化。组蛋白和其他染色质相关因子的翻译后蛋白质修饰是染色质动力学的重要调节剂。在这篇综述中，我们总结了表明通过小泛素相关修饰物 (SUMOs) 对蛋白质进行翻译后修饰可在多个层面调节染色质结构和功能，并通过多种机制影响基因表达和维持基因组完整性的研究。
