SUMO：一种具有多重功能的染色质结构和功能修饰物。
SUMO: a multifaceted modifier of chromatin structure and function.
机构信息
Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
出版信息
Dev Cell. 2013 Jan 14;24(1):1-12. doi: 10.1016/j.devcel.2012.11.020.
Abstract
A major challenge in nuclear organization is the packaging of DNA into dynamic chromatin structures that can respond to changes in the transcriptional requirements of the cell. Posttranslational protein modifications, of histones and other chromatin-associated factors, are essential regulators of chromatin dynamics. In this Review, we summarize studies demonstrating that posttranslational modification of proteins by small ubiquitin-related modifiers (SUMOs) regulates chromatin structure and function at multiple levels and through a variety of mechanisms to influence gene expression and maintain genome integrity.
摘要
核组织的一个主要挑战是将 DNA 包装成动态的染色质结构，以响应细胞转录需求的变化。组蛋白和其他染色质相关因子的翻译后蛋白质修饰是染色质动力学的重要调节剂。在这篇综述中，我们总结了表明通过小泛素相关修饰物 (SUMOs) 对蛋白质进行翻译后修饰可在多个层面调节染色质结构和功能，并通过多种机制影响基因表达和维持基因组完整性的研究。
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本文引用的文献
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Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions.泛素特异性蛋白酶样 1（USPL1）是一种 SUMO 异构酶，具有重要的非催化功能。
EMBO Rep. 2012 Oct;13(10):930-8. doi: 10.1038/embor.2012.125. Epub 2012 Aug 10.
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An acetylation switch regulates SUMO-dependent protein interaction networks.乙酰化开关调控 SUMO 依赖性蛋白相互作用网络。
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The SUMO protease SENP7 is a critical component to ensure HP1 enrichment at pericentric heterochromatin.SUMO 蛋白酶 SENP7 是确保 HP1 在着丝粒异染色质中富集的关键组成部分。
Nat Struct Mol Biol. 2012 Mar 4;19(4):458-60. doi: 10.1038/nsmb.2244.
4
Recognition of SUMO-modified PCNA requires tandem receptor motifs in Srs2.SUMO 修饰的 PCNA 的识别需要 Srs2 中的串联受体基序。
Nature. 2012 Feb 29;483(7387):59-63. doi: 10.1038/nature10883.
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SUMO conjugation is required for the assembly of Drosophila Su(Hw) and Mod(mdg4) into insulator bodies that facilitate insulator complex formation.SUMO 缀合对于果蝇 Su(Hw)和 Mod(mdg4)形成绝缘子体以促进绝缘子复合物形成是必需的。
J Cell Sci. 2012 Apr 15;125(Pt 8):2064-74. doi: 10.1242/jcs.100172. Epub 2012 Feb 28.
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Sumoylation of transcription factor Gcn4 facilitates its Srb10-mediated clearance from promoters in yeast.转录因子 Gcn4 的 SUMO 化促进了其在酵母中被 Srb10 介导从启动子上的清除。
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The SUMO E3 ligase Siz2 exerts a locus-dependent effect on gene silencing in Saccharomyces cerevisiae.SUMO E3连接酶Siz2对酿酒酵母中的基因沉默发挥基因座依赖性作用。
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Extensive DNA damage-induced sumoylation contributes to replication and repair and acts in addition to the mec1 checkpoint.广泛的 DNA 损伤诱导的 SUMO 化有助于复制和修复，并与 mec1 检查点一起发挥作用。
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