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本文引用的文献

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Serodiagnosis of tuberculosis in Asian elephants (Elephas maximus) in Southern India: a latent class analysis.印度南部亚洲象(Elephas maximus)结核病的血清学诊断:潜类别分析。
PLoS One. 2012;7(11):e49548. doi: 10.1371/journal.pone.0049548. Epub 2012 Nov 16.
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Tuberculosis at the human-animal interface: an emerging disease of elephants.人兽界面的结核病:大象的一种新兴疾病。
Tuberculosis (Edinb). 2011 May;91(3):208-11. doi: 10.1016/j.tube.2011.02.007. Epub 2011 Mar 11.
3
Elephant-to-human transmission of tuberculosis, 2009.2009 年发生的结核病的大象至人类传播。
Emerg Infect Dis. 2011 Mar;17(3):366-71. doi: 10.3201/eid1703.101668.
4
Tuberculosis in Africa--combating an HIV-driven crisis.非洲的结核病——应对由艾滋病毒引发的危机。
N Engl J Med. 2008 Mar 13;358(11):1089-92. doi: 10.1056/NEJMp0800809.
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Global phylogeography of Mycobacterium tuberculosis and implications for tuberculosis product development.结核分枝杆菌的全球系统发育地理学及其对结核病产品开发的影响。
Lancet Infect Dis. 2007 May;7(5):328-37. doi: 10.1016/S1473-3099(07)70108-1.
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Tuberculosis in elephants: antibody responses to defined antigens of Mycobacterium tuberculosis, potential for early diagnosis, and monitoring of treatment.大象的结核病:针对结核分枝杆菌特定抗原的抗体反应、早期诊断潜力及治疗监测
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Continuing Mycobacterium bovis transmission from animals to humans in New Zealand.新西兰牛型结核分枝杆菌持续从动物传播给人类。
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Mycobacterium tuberculosis: an emerging disease of free-ranging wildlife.结核分枝杆菌:一种在自由放养野生动物中出现的疾病。
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A multi-antigen print immunoassay for the development of serological diagnosis of infectious diseases.一种用于传染病血清学诊断发展的多抗原印迹免疫测定法。
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首例与人兽接触史相关的野生非洲象致死性肺结核病例报告。

First reported case of fatal tuberculosis in a wild African elephant with past human-wildlife contact.

机构信息

Veterinary Services Department, Kenya Wildlife Service, Nairobi, Kenya.

出版信息

Epidemiol Infect. 2013 Jul;141(7):1476-80. doi: 10.1017/S0950268813000022. Epub 2013 Jan 23.

DOI:10.1017/S0950268813000022
PMID:23340041
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9155287/
Abstract

Tuberculosis is emerging/re-emerging in captive elephant populations, where it causes morbidity and deaths, although no case of TB in wild African elephants has been reported. In this paper we report the first case of fatal TB in an African elephant in the wild. The infection with Mycobacterium tuberculosis was confirmed by post-mortem and histological examinations of a female sub-adult elephant aged >12 years that died in Tsavo East National Park, Kenya, while under treatment. This case is unique in that during its lifetime the elephant had contact with both humans and wild elephants. The source of the infection was unclear because the elephant could have acquired the infection in the orphanage or in the wild. However, our results show that wild elephants can maintain human TB in the wild and that the infection can be fatal.

摘要

结核病正在圈养象群中出现/再现,导致发病和死亡,尽管尚未有报道称野生非洲象患有结核病。本文报告了首例野生非洲象的致命结核病病例。通过对一只 12 岁以上的雌性亚成体大象的死后和组织学检查,确认其感染了结核分枝杆菌。这例病例是独一无二的,因为在其一生中,这头大象与人以及野生大象都有过接触。感染源尚不清楚,因为大象可能是在孤儿院或野外感染的。然而,我们的结果表明,野生大象可以在野外携带人类结核病,并且这种感染可能是致命的。