刺五加果实中的抗炎木脂素。
Anti-inflammatory lignans from the fruits of Acanthopanax sessiliflorus.
机构信息
Herbal Crop Utilization Research Team, National Institute of Horticultural and Herbal Science, RDA, Eumseong, Korea.
出版信息
Molecules. 2012 Dec 21;18(1):41-9. doi: 10.3390/molecules18010041.
A new lignan, named acanthosessilin A (1), as well as eight known lignan and lignan glycosides 2-9 were isolated from an ethanolic extract of Acanthopanax sessiliflorus fruits. The chemical structures were determined by spectroscopic methods, including HR-EIMS, 1D NMR (1H, 13C, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC, NOESY), and IR spectroscopy. All isolated compounds were tested for the ability to inhibit LPS-induced nitric oxide production in RAW264.7 macrophages.
从刺五加果实的乙醇提取物中分离得到一种新的木脂素，命名为 acanthosessilin A（1），以及八种已知的木脂素和木脂素糖苷 2-9。通过光谱方法，包括高分辨电喷雾电离质谱（HR-EIMS）、1D NMR（1H、13C、DEPT）、2D NMR（gCOSY、gHSQC、gHMBC、NOESY）和红外光谱，确定了它们的化学结构。所有分离得到的化合物均测试了其抑制 LPS 诱导的 RAW264.7 巨噬细胞中一氧化氮产生的能力。
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