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本文引用的文献

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Associations between matrix metalloproteinase-8 and -14 and myeloperoxidase in gingival crevicular fluid from subjects with progressive chronic periodontitis: a longitudinal study.基质金属蛋白酶-8 和 -14 与慢性进展性牙周炎患者龈沟液中髓过氧化物酶的相关性：一项纵向研究。
J Periodontol. 2010 Nov;81(11):1644-52. doi: 10.1902/jop.2010.100196. Epub 2010 Jul 27.
2
Association of fibronectin with hypogalactosylated immunoglobulin G in gingival crevicular fluid in periodontitis.纤维连接蛋白与牙周炎龈沟液中低半乳糖化免疫球蛋白 G 的关联。
J Periodontol. 2010 Oct;81(10):1472-80. doi: 10.1902/jop.2010.100053.
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A systematic review of definitions of periodontitis and methods that have been used to identify this disease.对牙周炎定义及用于识别该疾病的方法的系统评价。
J Clin Periodontol. 2009 Jun;36(6):458-67. doi: 10.1111/j.1600-051X.2009.01408.x.
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The importance of the study of the local metabolism in periodontal diseases.牙周疾病中局部代谢研究的重要性。
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Preparation and properties of serum and plasma proteins; the separation of purified fibrinogen from fraction I of human plasma.血清和血浆蛋白的制备及性质；从人血浆I组分中分离纯化纤维蛋白原。
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How human neutrophils kill and degrade microbes: an integrated view.人类中性粒细胞如何杀伤和降解微生物：综合观点。
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Gingival crevicular fluid osteopontin levels in periodontal health and disease.牙周健康与疾病状态下龈沟液中骨桥蛋白的水平
J Periodontol. 2006 Oct;77(10):1674-80. doi: 10.1902/jop.2006.060016.
8
Host-derived diagnostic markers for periodontitis: do they exist in gingival crevice fluid?牙周炎的宿主源性诊断标志物：它们存在于龈沟液中吗？
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Biochemical markers of the periodontal ligament.
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Gingival crevicular fluid collagenase-2 (MMP-8) test stick for chair-side monitoring of periodontitis.用于椅旁监测牙周炎的龈沟液胶原酶-2（基质金属蛋白酶-8）测试棒
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龈沟液作为牙周诊断指标——I：宿主来源的酶和组织分解产物

Gingival crevicular fluid as a periodontal diagnostic indicator--I: Host derived enzymes and tissue breakdown products.

作者信息

Gupta G

机构信息

Department of Periodontics, Institute of Dental Studies and Technologies, Modinagar.

出版信息

J Med Life. 2012 Dec 15;5(4):390-7. Epub 2012 Dec 25.

PMID:23346239
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3539845/
Abstract

Researchers involved in the delivery of periodontal therapy are currently investigating the possible use of oral fluids in the diagnosis of oral diseases and drug development. Substantial improvements have been made in the understanding of the mediators implicated on the initiation, pathogenesis, and progression of periodontitis. This review will analyze the mechanisms involved in the breakdown of periodontal supporting tissues during chronic periodontitis and highlights the potential array of biomarkers present in gingival crevicular fluid (GCF), which may relate to existing or predicted tissue regions undergoing metabolic change.

摘要

参与牙周治疗的研究人员目前正在研究口腔液体在口腔疾病诊断和药物开发中的潜在用途。在对与牙周炎的发生、发病机制和进展相关的介质的理解方面已经取得了重大进展。本综述将分析慢性牙周炎期间牙周支持组织破坏所涉及的机制，并重点介绍龈沟液（GCF）中存在的一系列潜在生物标志物，这些生物标志物可能与正在经历代谢变化的现有或预测组织区域有关。