Zuo Yu, Foshat Michelle, Qian You-Wen, Kelly Brent, Harper Brock, Karnath Bernard
Department of Internal Medicine, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA.
Case Rep Rheumatol. 2012;2012:325062. doi: 10.1155/2012/325062. Epub 2012 Dec 30.
Kikuchi Fujimoto's disease (KFD) is a rare, immune-mediated, self-limiting disorder with unique histopathological features. KFD is usually seen in young Asian females; however, cases have been reported throughout the world and in all ethnicities. It has been recognized that there is a rare association between Systemic Lupus Erythematosus (SLE) and KFD via sporadic case reports. The exact pathophysiological relationship between these two diseases is still unclear. We report a case of a young Asian female who presented with persistent fever and lymphadenopathy and was diagnosed with Kikuchi Fujimoto's disease based on lymph node biopsy; although an SLE workup was done, she did not meet the American Rheumatology Association (ARA) diagnostic criteria for lupus, and the lymph node biopsy did not show features of SLE. She improved clinically with a short course of steroid therapy. Two months later, the patient presented with central facial rash and arthralgia. SLE workup was repeated, a skin biopsy was done, and the results at this time supported a diagnosis of SLE.
菊池富士本病（KFD）是一种罕见的、免疫介导的自限性疾病，具有独特的组织病理学特征。KFD通常见于年轻的亚洲女性；然而，世界各地及所有种族均有病例报道。通过散发病例报告已认识到系统性红斑狼疮（SLE）与KFD之间存在罕见关联。这两种疾病的确切病理生理关系仍不清楚。我们报告一例年轻亚洲女性病例，该患者表现为持续发热和淋巴结病，基于淋巴结活检被诊断为菊池富士本病；尽管进行了SLE检查，但她不符合美国风湿病学会（ARA）的狼疮诊断标准，且淋巴结活检未显示SLE特征。她通过短期类固醇治疗临床症状改善。两个月后，患者出现面部中央皮疹和关节痛。再次进行SLE检查，并进行了皮肤活检，此时的结果支持SLE诊断。
