壳聚糖修饰的石墨烯纳米凝胶用于非侵入式控制药物释放。
A chitosan-modified graphene nanogel for noninvasive controlled drug release.
机构信息
Molecular Medicine Department, Morsani College of Medicine, University of South Florida, Tampa, FL, USA; USF Nanomedicine Research Center, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
出版信息
Nanomedicine. 2013 Oct;9(7):903-11. doi: 10.1016/j.nano.2013.01.003. Epub 2013 Jan 22.
UNLABELLED
A near infrared (NIR) triggered drug delivery platform based on the chitosan-modified chemically reduced graphene oxide (CRGO) incorporated into a thermosensitive nanogel (CGN) was developed. CGN exhibited an NIR-induced thermal effect similar to that of CRGO, reversible thermo-responsive characteristics at 37-42 °C and high doxorubicin hydrochloride (DOX) loading capacity (48 wt%). The DOX loaded CGN (DOX-CGN) released DOX faster at 42 °C than at 37 °C. The fluorescence images revealed DOX expression in the cytoplasm of cancer cells when incubated with DOX-CGN at 37 °C but in the nucleus at 42 °C. Upon irradiation with NIR light (808 nm), a rapid, repetitive DOX release from the DOX-CGN was observed. Furthermore, the cancer cells incubated with DOX-CGN and irradiated with NIR light displayed significantly greater cytotoxicity than without irradiation owing to NIR-triggered increase in temperature leading to nuclear DOX release. These results demonstrate CGN's promising application for on-demand drug release by NIR light.
FROM THE CLINICAL EDITOR
These investigators report the successful development of a novel near infrared triggered drug delivery platform based on chitosan-modified chemically reduced graphene oxide (CRGO) incorporated into a thermosensitive nanogel (CGN).
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开发了一种基于壳聚糖修饰的化学还原氧化石墨烯（CRGO）的近红外（NIR）触发药物输送平台，该平台被整合到热敏纳米凝胶（CGN）中。CGN 表现出与 CRGO 相似的 NIR 诱导热效应，在 37-42°C 具有可逆的热响应特性，并且具有高盐酸阿霉素（DOX）负载能力（48wt%）。负载 DOX 的 CGN（DOX-CGN）在 42°C 时比在 37°C 时更快地释放 DOX。荧光图像显示，当 DOX-CGN 在 37°C 下孵育时，DOX 在癌细胞的细胞质中表达，但在 42°C 时在细胞核中表达。用近红外光（808nm）照射后，观察到 DOX-CGN 快速、重复地释放 DOX。此外，与未照射的癌细胞相比，用 DOX-CGN 孵育并用光照射的癌细胞显示出显著更高的细胞毒性，这是由于近红外光引发的温度升高导致核 DOX 释放。这些结果表明 CGN 有望通过近红外光实现按需药物释放。
临床编辑
这些研究人员报告了一种新型近红外触发药物输送平台的成功开发，该平台基于壳聚糖修饰的化学还原氧化石墨烯（CRGO）整合到热敏纳米凝胶（CGN）中。
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