声化学法制备具有选择性抗菌活性的聚多巴胺纳米胶囊。
Sonochemically produced polydopamine nanocapsules with selective antimicrobial activity.
机构信息
Department of Chemistry, Bar-Ilan University, Ramat-Gan 52900, Israel.
出版信息
Chem Commun (Camb). 2013 Jun 28;49(51):5721-3. doi: 10.1039/c3cc37762h.
A facile, versatile, and one-pot sonochemical synthesis of polydopamine (PDA)-nanocapsules from dopamine is reported. The nanocapsules (227 ± 25 nm) can encapsulate hydrophobic substances while retaining the reactivity of PDA toward nucleophilic reactions, enabling facile surface modification for different applications. PDA nanocapsules are nontoxic to mammalian cells while Cu-containing PDA capsules demonstrate strong (99.9%) and rapid (15 min) bactericidal activity.
本文报道了一种简便、通用、一锅超声化学法从多巴胺制备聚多巴胺（PDA）纳米胶囊的方法。该纳米胶囊（227 ± 25nm）可包封疏水性物质，同时保持 PDA 对亲核反应的反应性，便于进行不同应用的表面改性。PDA 纳米胶囊对哺乳动物细胞无毒，而含 Cu 的 PDA 胶囊则表现出很强的（99.9%）和快速的（15min）杀菌活性。
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