Department of Infectious Diseases, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
BMC Infect Dis. 2013 Feb 11;13:79. doi: 10.1186/1471-2334-13-79.
The prevalence of hyperglycemia among HIV-infected persons who are not receiving antiretroviral therapy is unknown. We conducted a cross-sectional survey to estimate the prevalence of hyperglycemia among Chinese adults with newly diagnosed HIV/AIDS.
Two thousand and six newly diagnosed HIV/AIDS patients from 10 provinces and municipalities in China were selected during 2009 to 2010. After an overnight fast, serum samples were collected to measure glucose concentrations. Demographics and medical histories were recorded. Factors associated with the presence of diabetes were analysed by logistic regression.
Among the 2006 patients, 75.67% were male. Median age was 40 years (range: 18-86 years). 19.99% had hyperglycemia, 9.47% had impaired fasting glucose (IFG) and 10.52% had diabetes. The prevalences of hyperglycemia, of IFG and of diabetes were 21.54%, 10.28% and 11.27% among men and 15.16%, 6.97% and 8.20% among women, respectively. The prevalence of diabetes increased with increasing age (7.00%, 13.36% and 21.21% among patients who were 18-40, 40-60, and ≥60 years of age respectively) and with decreasing CD4 count (6.74%, 8.45%, 9.69%, and 12.66% among patients with CD4 count of ≥350, 200-350, 50-200, and < 50/mm3 respectively). The prevalence of diabetes was higher among ethnic minority patients than among the Han patients (14.37% versus 9.24%). The logistic analysis showed that older age, lower CD4 count and minority ethnicity were significantly associated with an increased risk of diabetes.
Hyperglycemia is highly prevalent among Chinese adults with newly diagnosed HIV/AIDS. Older age, lower CD4 count and minority ethnicity are associated with increased risk of diabetes. All newly diagnosed HIV/AIDS individuals should be routinely evaluated for hyperglycemia.
未接受抗逆转录病毒治疗的 HIV 感染者中高血糖的患病率尚不清楚。我们进行了一项横断面调查，以估计中国新诊断 HIV/AIDS 成人中高血糖的患病率。
2009 年至 2010 年期间，我们从中国 10 个省和直辖市选择了 2006 例新诊断的 HIV/AIDS 患者。空腹过夜后，采集血清样本测量血糖浓度。记录人口统计学和病史。采用 logistic 回归分析与糖尿病存在相关的因素。
在 2006 例患者中，75.67%为男性。中位年龄为 40 岁（范围：18-86 岁）。19.99%有高血糖，9.47%有空腹血糖受损（IFG），10.52%有糖尿病。男性高血糖、IFG 和糖尿病的患病率分别为 21.54%、10.28%和 11.27%，女性分别为 15.16%、6.97%和 8.20%。糖尿病的患病率随年龄增长而增加（18-40 岁、40-60 岁和≥60 岁的患者分别为 7.00%、13.36%和 21.21%），随 CD4 计数减少而增加（CD4 计数≥350、200-350、50-200 和<50/mm3 的患者分别为 6.74%、8.45%、9.69%和 12.66%）。少数民族患者的糖尿病患病率高于汉族患者（14.37%比 9.24%）。logistic 分析显示，年龄较大、CD4 计数较低和少数民族与糖尿病风险增加显著相关。
中国新诊断 HIV/AIDS 成人中高血糖患病率很高。年龄较大、CD4 计数较低和少数民族与糖尿病风险增加相关。所有新诊断的 HIV/AIDS 患者均应常规评估高血糖。
