Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Human Development and Health, Institute of Developmental Sciences, University of Southampton, Southampton SO16 6YD, United Kingdom.
ACS Nano. 2013 Mar 26;7(3):1867-81. doi: 10.1021/nn3037094. Epub 2013 Feb 15.
Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have the capacity to differentiate into any specialized cell type of the human body, and therefore, ESC/iPSC-derived cell types offer great potential for regenerative medicine. However, key to realizing this potential requires a strong understanding of stem cell biology, techniques to maintain stem cells, and strategies to manipulate cells to efficiently direct cell differentiation toward a desired cell type. As nanoscale science and engineering continues to produce novel nanotechnology platforms, which inform, infiltrate, and impinge on many aspects of everyday life, it is no surprise that stem cell research is turning toward developments in nanotechnology to answer research questions and to overcome obstacles in regenerative medicine. Here we discuss recent advances in ESC and iPSC manipulation using nanomaterials and highlight future challenges within this area of research.
胚胎干细胞（ESCs）和诱导多能干细胞（iPSCs）具有分化为人体任何特定细胞类型的能力，因此，ESC/iPSC 衍生的细胞类型为再生医学提供了巨大的潜力。然而，要实现这一潜力的关键需要深入了解干细胞生物学、维持干细胞的技术以及操纵细胞的策略，以有效地将细胞定向分化为所需的细胞类型。随着纳米科学和工程的不断发展，产生了许多新颖的纳米技术平台，这些平台影响并渗透到日常生活的许多方面，因此干细胞研究转向纳米技术的发展也就不足为奇了，这是为了回答研究问题并克服再生医学中的障碍。在这里，我们讨论了使用纳米材料对 ESC 和 iPSC 进行操作的最新进展，并强调了该研究领域的未来挑战。
