Department of Radiology, Seoul National University College of Medicine, Seoul 110-744, Korea.
Korean J Radiol. 2013 Mar-Apr;14(2):194-201. doi: 10.3348/kjr.2013.14.2.194. Epub 2013 Feb 22.
To determine in vivo efficacy of radiofrequency ablation (RFA) in porcine liver by using 15-gauge Octopus® (15-G Octopus®) electrodes to create a large coagulation.
A total of 18 coagulations were created by using a 180-W generator and 15-G Octopus® electrodes during laparotomy, performed in 14 pigs. Coagulation necrosis was created in the pig livers by the use of one of three RFA protocols: 1) group A, monopolar RFA using a 15-G Octopus® electrode with a 5-mm inter-electrode distance (n = 4); 2) group B, monopolar RFA using a 15-G Octopus® electrode with a 10-mm inter-electrode distance (n = 6); and 3) group C, switching monopolar RFA using two 15-G Octopus® electrodes (n = 8). The energy efficiency, shape, maximum and minimum diameters (Dmx and Dmi), and the volume of the coagulation volume were measured in each group. The Summary statistics were obtained and Mann-Whitney test was were performed.
The mean ablated volume of each group was 49.23 cm(3) in A, 64.11 cm(3) in B, and 72.35 cm(3) in C. The mean Dmx and Dmi values were 5.68 cm and 4.58 cm in A and 5.97 cm and 4.97 cm in B, respectively. In group C, the mean diameters of Dmx and Dmi were 6.80 cm and 5.11 cm, respectively. The mean ratios of Dmi/Dmx were 1.25, 1.20, and 1.35 in groups A, B, and C, respectively. There was one animal death during the RFA procedure, the cause of which could not be subsequently determined. However, there were no other significant, procedure-related complications during the seven-hour-delayed CT scans.
RFA procedures using 15-G Octopus® electrodes are useful and safe for creating a large ablation in a single electrode model as well as in the multiple electrodes model.
使用 15 号八角针（15-G Octopus®）电极在猪肝脏内进行射频消融（RFA），以确定其体内疗效，从而产生大的凝固区。
在 14 头猪的剖腹手术中，使用 180-W 发生器和 15-G Octopus®电极共创建了 18 个凝固区。通过使用三种 RFA 方案之一在猪肝脏中产生凝固性坏死：1）组 A，使用 5-mm 电极间距的 15-G Octopus®单极 RFA（n = 4）；2）组 B，使用 10-mm 电极间距的 15-G Octopus®单极 RFA（n = 6）；和 3）组 C，使用两个 15-G Octopus®电极切换单极 RFA（n = 8）。在每组中测量能量效率、形状、最大和最小直径（Dmx 和 Dmi）以及凝固体积。获得汇总统计数据并进行了 Mann-Whitney 检验。
A 组每个消融区域的平均消融体积为 49.23cm³，B 组为 64.11cm³，C 组为 72.35cm³。A 组和 B 组的平均 Dmx 和 Dmi 值分别为 5.68cm 和 4.58cm，Dmx 和 Dmi 值分别为 5.97cm 和 4.97cm。C 组的平均 Dmx 和 Dmi 值分别为 6.80cm 和 5.11cm，Dmi/Dmx 的平均比值分别为 1.25、1.20 和 1.35。在 RFA 过程中有一只动物死亡，其原因无法确定。然而，在七小时延迟 CT 扫描过程中，没有其他与程序相关的重大并发症。
使用 15-G Octopus®电极的 RFA 程序在单电极模型和多电极模型中创建大的消融区域是有用且安全的。
