Chen Y, Wang B M, Li C Y, Yu D J
Institute of Hematology, Xiehe Hospital, Tongji Medical University, Wuhan.
J Tongji Med Univ. 1990;10(1):23-6. doi: 10.1007/BF02909117.
We observed CFU-Mix of 4 normal adults and 11 cases of leukemia. The culture system used by us in this study represented a suitable model for studying differentiation of hemopoietic stem cells in vitro. The pathogenesis of myeloid-lymphoid bipotent leukemia were malignant changes in pluripotent hemopoietic progenitor cells. The leukemic clones showed proliferation, but did not mature in culture. It is suggested that differentiation of leukemic stem cell did not pass through CFU-Mix stage.
我们观察了4名正常成年人和11例白血病患者的混合集落形成单位（CFU-Mix）。我们在本研究中使用的培养系统是体外研究造血干细胞分化的合适模型。髓系-淋巴系双能白血病的发病机制是多能造血祖细胞的恶性改变。白血病克隆在培养中表现出增殖，但未成熟。提示白血病干细胞的分化未经过CFU-Mix阶段。
