前列腺癌中的锌转运体。
Zinc transporters in prostate cancer.
机构信息
Institute of Biochemistry and Molecular Medicine, University of Bern, Switzerland.
出版信息
Mol Aspects Med. 2013 Apr-Jun;34(2-3):735-41. doi: 10.1016/j.mam.2012.11.007.
Abstract
Prostate cancer is a major health concern as it has the second highest incidence rate among cancers in men. Despite progress in tumor diagnostics and therapeutic approaches, prognosis for men with advanced disease remains poor. In this review we provide insight into the changes of the intermediary metabolism in normal prostate and prostate cancer. In contrast to normal cells, prostate cancer cells are reprogrammed for optimal energy-efficiency with a functional Krebs cycle and minimal apoptosis rates. A key element in this relationship is the uniquely high zinc level of normal prostate epithelial cells. Zinc is transported by the SLC30 and SLC39 families of zinc transporters. However, in prostate cancer the intracellular zinc content is remarkably reduced and expression levels of certain zinc transporters are altered. Here, we summarize the role of different zinc transporters in the development of prostate cancer.
摘要
前列腺癌是一个主要的健康关注点，因为它是男性癌症中发病率第二高的癌症。尽管在肿瘤诊断和治疗方法方面取得了进展，但晚期疾病患者的预后仍然很差。在这篇综述中，我们深入了解了正常前列腺和前列腺癌中中间代谢的变化。与正常细胞不同，前列腺癌细胞通过功能齐全的克雷布斯循环和最小的细胞凋亡率被重新编程以实现最佳的能量效率。这种关系的一个关键因素是正常前列腺上皮细胞中独特的高锌水平。锌由 SLC30 和 SLC39 家族的锌转运蛋白转运。然而，在前列腺癌中，细胞内锌含量显著降低，某些锌转运蛋白的表达水平也发生改变。在这里，我们总结了不同锌转运蛋白在前列腺癌发展中的作用。
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