Department of Chemical and Biomolecular Engineering, University of Melbourne, Australia.
Nanotechnology. 2013 Apr 19;24(15):155101. doi: 10.1088/0957-4484/24/15/155101. Epub 2013 Mar 22.
Bacteria colonization on medical devices remains one of the most serious complications following implantation. Traditional antibiotic treatment has proven ineffective, creating an increasingly high number of drug-resistant bacteria. Polymeric medical devices represent a significant portion of the total medical devices used today due to their excellent mechanical properties (such as durability, flexibility, etc). However, many polymers (such as polyvinyl chloride (PVC), polyurethane (PU) and silicone) become readily colonized and infected by bacteria immediately after use. Therefore, in this study, a novel antimicrobial coating was developed to inhibit bacterial growth on PVC, PU and silicone. Specifically, here, the aforementioned polymeric substrates were coated with selenium (Se) nanoparticles in situ. The Se-coated substrates were characterized using scanning electron microscopy, energy dispersive x-ray spectroscopy and bacteria assays. Most importantly, bacterial growth was significantly inhibited on the Se-coated substrates compared to their uncoated counterparts. The reduction of bacteria growth directly correlated with the density of Se nanoparticles on the coated substrate surfaces. In summary, these results demonstrate that Se should be further studied as a novel anti-bacterial polymeric coating material which can decrease bacteria functions without the use of antibiotics.
医疗器械上的细菌定植仍然是植入后最严重的并发症之一。传统的抗生素治疗已被证明无效，导致越来越多的耐药菌产生。由于具有优异的机械性能（如耐用性、柔韧性等），聚合物医疗器械在当今使用的所有医疗器械中占据了很大比例。然而，许多聚合物（如聚氯乙烯（PVC）、聚氨酯（PU）和硅橡胶）在使用后很容易被细菌定植和感染。因此，在这项研究中，开发了一种新型抗菌涂层，以抑制 PVC、PU 和硅橡胶上的细菌生长。具体来说，在这里，将上述聚合物基质用硒（Se）纳米粒子进行原位涂层。使用扫描电子显微镜、能谱和细菌检测对 Se 涂层的基底进行了表征。最重要的是，与未涂层的对照相比，Se 涂层的基底上的细菌生长明显受到抑制。细菌生长的减少与涂层基底表面上 Se 纳米粒子的密度直接相关。总之，这些结果表明，硒应该作为一种新型的抗菌聚合物涂层材料进行进一步研究，这种材料可以在不使用抗生素的情况下降低细菌的功能。
