Oge T, Yalcin O T, Ozalp S S, Isikci T
Department of Gynecology and Obstetrics, Eskisehir Osmangazi University School of Medicine, Eskisehir, Turkey.
J Obstet Gynaecol. 2013 Apr;33(3):301-4. doi: 10.3109/01443615.2012.758089.
The objective of this study was to use mean platelet volume (MPV) as a measure of platelet activation in patients with endometrial adenocarcinoma and healthy controls. There was a total of 310 patients with endometrial adenocarcinoma retrospectively evaluated and 250 healthy controls. Preoperative haemoglobin, platelet counts and mean platelet volume were evaluated and statistical tests were conducted to determine the differences among early and advanced disease groups and controls. Median haemoglobin (13.0 vs 13.3 g/dl) and platelet count (282,000 vs 280,000/μl) values were similar in patients with endometrial adenocarcinoma and healthy controls (p > 0.05). Subjects with endometrial cancer exhibited slightly higher MPV than the control group (8.4 fl vs 8.2 fl) (p = 0.048). In patients with advanced-stage endometrial cancer, haemoglobin was significantly lower (p < 0.05) and MPV was significantly higher (p < 0.05) than in either patients with early-stage endometrial cancer or the control group. It was concluded that MPV was found to be a marker for predicting advanced-stage endometrial cancers.
本研究的目的是使用平均血小板体积（MPV）作为子宫内膜腺癌患者和健康对照者血小板活化的一项指标。总共对310例子宫内膜腺癌患者进行了回顾性评估，并设置了250名健康对照者。对术前血红蛋白、血小板计数和平均血小板体积进行了评估，并进行了统计检验以确定早期和晚期疾病组与对照组之间的差异。子宫内膜腺癌患者和健康对照者的血红蛋白中位数（13.0对13.3 g/dl）和血小板计数（282,000对280,000/μl）值相似（p>0.05）。子宫内膜癌患者的MPV略高于对照组（8.4 fl对8.2 fl）（p = 0.048）。晚期子宫内膜癌患者的血红蛋白显著低于（p<0.05）早期子宫内膜癌患者或对照组，而MPV则显著高于（p<0.05）早期子宫内膜癌患者或对照组。研究得出结论，MPV可作为预测晚期子宫内膜癌的一个标志物。
