Institut de Recherche en Sciences de la Santé, 399 Avenue de la liberté, Bobo-Dioulasso BP 545, Burkina Faso.
BMC Infect Dis. 2013 Apr 4;13:164. doi: 10.1186/1471-2334-13-164.
Despite the serious consequences of rubella infection during early pregnancy, very little is known about the rubella seroprevalence in a number of African countries including Burkina Faso.
Between December 2007 and March 2008 serum samples were collected from 341 pregnant women in Bobo (n = 132, urban area) and Houndé (n = 209, rural area) and were tested for rubella-specific IgG antibodies with a commercial ELISA kit.
An overall seropositivity rate of 95.0% (324/341) was found, with a higher percentage in the urban population and in the oldest age group. Considering an antibody titer of at least 10 International Units per ml as protective, the overall immunity rate in the cohort of pregnant women was 93.3% (318/341).
The high overall seropositivity rate in the absence of routine immunization suggests a continuous transmission of endemic rubella virus in Burkina Faso, posing a threat to non-immune pregnant women.
尽管风疹感染在妊娠早期会导致严重后果，但在包括布基纳法索在内的一些非洲国家，人们对风疹血清流行率知之甚少。
2007 年 12 月至 2008 年 3 月，从博博（城市地区，n = 132）和洪德（农村地区，n = 209）的 341 名孕妇中采集血清样本，并使用商业 ELISA 试剂盒检测风疹特异性 IgG 抗体。
发现总血清阳性率为 95.0%（324/341），城市人口和最年长的年龄组阳性率更高。考虑到抗体滴度至少为 10 国际单位/毫升为保护性，孕妇队列的总免疫率为 93.3%（318/341）。
在没有常规免疫接种的情况下，总体血清阳性率较高表明布基纳法索地方性风疹病毒持续传播，对非免疫孕妇构成威胁。
