大鼠连续91天重复给药后黑希拉季特安全性评估。
Evaluation of safety profile of black shilajit after 91 days repeated administration in rats.
作者信息
Velmurugan C, Vivek B, Wilson E, Bharathi T, Sundaram T
机构信息
Department of Pharmacology, Sri Krishna Chaithanya College of Pharmacy, Nimnapalli Road, Madanapalle, Andhra Pradesh.
出版信息
Asian Pac J Trop Biomed. 2012 Mar;2(3):210-4. doi: 10.1016/S2221-1691(12)60043-4.
OBJECTIVE
To evaluate the safety of shilajit by 91 days repeated administration in different dose levels in rats.
METHODS
In this study the albino rats were divided into four groups. Group I received vehicle and group II, III and IV received 500, 2 500 and 5 000 mg/kg of shilajit, respectively. Finally animals were sacrificed and subjected to histopathology and iron was estimated by flame atomic absorption spectroscopy and graphite furnace.
RESULTS
The result showed that there were no significant changes in iron level of treated groups when compared with control except liver (5 000 mg/kg) and histological slides of all organs revealed normal except negligible changes in liver and intestine with the highest dose of shilajit. The weight of all organs was normal when compared with control.
CONCLUSIONS
The result suggests that black shilajit, an Ayurvedic formulation, is safe for long term use as a dietary supplement for a number of disorders like iron deficiency anaemia.
目的
通过在大鼠中进行91天不同剂量水平的重复给药来评估希拉季特的安全性。
方法
在本研究中，将白化大鼠分为四组。第一组接受赋形剂，第二、三、四组分别接受500、2500和5000毫克/千克的希拉季特。最后处死动物并进行组织病理学检查，通过火焰原子吸收光谱法和石墨炉法测定铁含量。
结果
结果表明，与对照组相比，除肝脏（5000毫克/千克）外，治疗组的铁水平无显著变化，所有器官的组织切片均显示正常，除了希拉季特最高剂量组的肝脏和肠道有轻微变化。与对照组相比，所有器官的重量均正常。
结论
结果表明，阿育吠陀制剂黑希拉季特作为缺铁性贫血等多种疾病的膳食补充剂长期使用是安全的。
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