Department of Experimental Molecular Imaging, University Clinic and Helmholtz Institute for Biomedical Engineering, RWTH - Aachen University, Aachen, Germany.
Curr Opin Biotechnol. 2013 Dec;24(6):1159-66. doi: 10.1016/j.copbio.2013.02.020. Epub 2013 Apr 9.
In recent years, the use of nanomedicine formulations for therapeutic and diagnostic applications has increased exponentially. Many different systems and strategies have been developed for drug targeting to pathological sites, as well as for visualizing and quantifying important (patho-) physiological processes. In addition, ever more efforts have been undertaken to combine diagnostic and therapeutic properties within a single nanomedicine formulation. These so-called nanotheranostics are able to provide valuable information on drug delivery, drug release and drug efficacy, and they are considered to be highly useful for personalizing nanomedicine-based (chemo-) therapeutic interventions.
近年来,纳米医学制剂在治疗和诊断应用中的使用呈指数级增长。已经开发出许多不同的系统和策略,用于将药物靶向到病理部位,以及用于可视化和量化重要的(病理)生理过程。此外,人们还越来越努力地将诊断和治疗特性结合在单个纳米医学制剂中。这些所谓的纳米治疗剂能够提供关于药物输送、药物释放和药物疗效的有价值的信息,并且被认为对基于纳米医学的(化学)治疗干预的个体化非常有用。