Neuroscience Program, University of Illinois, Urbana, IL 61801, USA.
J Cell Mol Med. 2013 May;17(5):597-604. doi: 10.1111/jcmm.12045. Epub 2013 Apr 18.
Living cells are continuously exposed to mechanical cues, and can translate these signals into biochemical information (e.g. mechanotransduction). This process is crucial in many normal cellular functions, e.g. cell adhesion, migration, proliferation, and survival, as well as the progression of diseases such as cancer. Focal adhesions are the major sites of interactions between extracellular mechanical environments and intracellular biochemical signalling molecules/cytoskeleton, and hence focal adhesion proteins have been suggested to play important roles in mechanotransduction. Here, we overview the current molecular understanding in mechanotransduction occurring at focal adhesions. We also introduce recent studies on how extracellular matrix and mechanical microenvironments contribute to the development of cancer.
活细胞不断受到机械线索的影响，并将这些信号转化为生化信息（例如力学转导）。这个过程在许多正常细胞功能中至关重要，例如细胞黏附、迁移、增殖和存活，以及癌症等疾病的进展。黏附斑是细胞外机械环境与细胞内生化信号分子/细胞骨架相互作用的主要部位，因此黏附斑蛋白被认为在力学转导中发挥重要作用。在这里，我们综述了目前对黏附斑处力学转导的分子认识。我们还介绍了最近关于细胞外基质和机械微环境如何促进癌症发展的研究。
