Expressed protein ligation at methionine: N-terminal attachment of homocysteine, ligation, and masking.
作者信息
Tanaka Tomohiro, Wagner Anne M, Warner John B, Wang Yanxin J, Petersson E James
机构信息
Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104-6323, USA.
出版信息
Angew Chem Int Ed Engl. 2013 Jun 10;52(24):6210-3. doi: 10.1002/anie.201302065. Epub 2013 Apr 29.
Abstract
摘要
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Characterization of semisynthetic and naturally Nα-acetylated α-synuclein in vitro and in intact cells: implications for aggregation and cellular properties of α-synuclein.体外和完整细胞中半合成和天然 Nα-乙酰化的α-突触核蛋白的特性：对α-突触核蛋白聚集和细胞特性的影响。
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N-terminal deletion does not affect α-synuclein membrane binding, self-association and toxicity in human neuroblastoma cells, unlike yeast.与酵母不同，N 端缺失并不影响人神经母细胞瘤细胞中α-突触核蛋白与膜的结合、自聚集和毒性。
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The N-terminus of the intrinsically disordered protein α-synuclein triggers membrane binding and helix folding.α-突触核蛋白无规则卷曲结构的 N 端结构域触发膜结合和螺旋折叠。
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