Provident Clinical Research and Consulting, Inc., Glen Ellyn, IL, USA.
J Nutr. 2012 Apr;142(4):717-23. doi: 10.3945/jn.111.152975. Epub 2012 Feb 22.
This study evaluated the effects of 2 levels of intake of high-amylose maize type 2 resistant starch (HAM-RS2) on insulin sensitivity (S(I)) in participants with waist circumference ≥89 (women) or ≥102 cm (men). Participants received 0 (control starch), 15, or 30 g/d (double-blind) of HAM-RS2 in random order for 4-wk periods separated by 3-wk washouts. Minimal model S(I) was assessed at the end of each period using the insulin-modified i.v. glucose tolerance test. The efficacy evaluable sample included 11 men and 22 women (mean ± SEM) age 49.5 ± 1.6 y, with a BMI of 30.6 ± 0.5 kg/m2 and waist circumference 105.3 ± 1.3 cm. A treatment main effect (P = 0.018) and a treatment × sex interaction (P = 0.033) were present. In men, least squares geometric mean analysis for S(I) did not differ after intake of 15 g/d HAM-RS2 (6.90 × 10⁻⁵ pmol⁻¹ · L⁻¹ × min⁻¹) and 30 g/d HAM-RS2 (7.13 × 10⁻⁵ pmol⁻¹ · L⁻¹ × min⁻¹), but both were higher than after the control treatment (4.66 × 10⁻⁵ pmol⁻¹ · L⁻¹ × min⁻¹) (P < 0.05). In women, there was no difference among the treatments (overall least squares ln-transformed mean ± pooled SEM = 1.80 ± 0.08; geometric mean = 6.05 × 10⁻⁵ pmol⁻¹ · L⁻¹ × min⁻¹). These results suggest that consumption of 15-30 g/d of HAM-RS2 improves S(I) in men. Additional research is needed to understand the mechanisms that might account for the treatment × sex interaction observed.
本研究评估了两种水平的高直链淀粉玉米 2 型抗性淀粉（HAM-RS2）摄入对腰围≥89（女性）或≥102cm（男性）的参与者胰岛素敏感性（S（I））的影响。参与者以随机顺序接受 0（对照淀粉）、15 或 30g/d 的 HAM-RS2（双盲），每个周期持续 4 周，间隔 3 周洗脱期。在每个周期结束时，使用胰岛素改良静脉葡萄糖耐量试验评估最小模型 S（I）。可评估疗效的样本包括 11 名男性和 22 名女性（平均±SEM），年龄 49.5±1.6 岁，BMI 为 30.6±0.5kg/m2，腰围 105.3±1.3cm。存在治疗主效应（P=0.018）和治疗×性别交互作用（P=0.033）。在男性中，S（I）的最小二乘几何均数分析在摄入 15g/d HAM-RS2（6.90×10⁻⁵ pmol⁻¹·L⁻¹·min⁻¹）和 30g/d HAM-RS2（7.13×10⁻⁵ pmol⁻¹·L⁻¹·min⁻¹）后没有差异，但均高于对照处理（4.66×10⁻⁵ pmol⁻¹·L⁻¹·min⁻¹）（P<0.05）。在女性中，各处理之间无差异（总体最小二乘对数变换均值±pooled SEM=1.80±0.08；几何均值=6.05×10⁻⁵ pmol⁻¹·L⁻¹·min⁻¹）。这些结果表明，摄入 15-30g/d 的 HAM-RS2 可改善男性的 S（I）。需要进一步研究以了解可能解释观察到的治疗×性别相互作用的机制。
