大鼠的移位物体识别记忆
Displaced Object Recognition Memory in Rats.
作者信息
Mclagan Ali N, Hales Jena B
机构信息
Department of Psychological Sciences, University of San Diego, San Diego, CA, USA.
出版信息
Bio Protoc. 2019 Apr 20;9(8):e3212. doi: 10.21769/BioProtoc.3212.
The Displaced Object Recognition (DOR) task, sometimes called the Novel Object Location task, assesses spatial recognition memory without navigational demands, explicit instruction, or the need for multiple days of training. This memory task has two phases. First, the subject is familiarized to an open arena with two objects and is allowed to explore the objects. Following a delay period, the subject returns to the arena, but one of the previous objects has been moved to a new location. Greater exploration of the displaced object is used as the index of memory for the previous object location. An advantage of the DOR task is that subjects can be tested without explicit training, since this task exploits the natural tendency to be more interested in something novel. The spontaneous aspect of this task allows for the testing of animals as well as human populations that are unable to follow verbal instructions, such as babies. Therefore, this powerful test of recognition memory can be administered similarly for many species, including rats and humans, allowing for better translatability.
移位物体识别（DOR）任务，有时也称为新物体定位任务，可在无需导航要求、明确指令或多天训练的情况下评估空间识别记忆。此记忆任务有两个阶段。首先，让受试者熟悉一个有两个物体的开放场地，并允许其探索这些物体。经过一段延迟期后，受试者回到场地，但之前的一个物体已被移到新位置。对移位物体的更多探索被用作对先前物体位置记忆的指标。DOR任务的一个优点是，受试者无需经过明确训练即可进行测试，因为该任务利用了对新奇事物更感兴趣的自然倾向。此任务的自发性使得它可用于测试动物以及无法遵循口头指令的人群，如婴儿。因此，这种强大的识别记忆测试可对包括大鼠和人类在内的许多物种以类似方式进行，具有更好的可翻译性。
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