University of California, San Diego, La Jolla, CA, USA
Emerg Infect Dis. 2013 May;19(5):802-5. doi: 10.3201/eid1905.121852.
Patients with Plasmodium vivax malaria are treated with primaquine to prevent relapse infections. We report primaquine failure in a patient with 3 relapses without any possibility of re-infection. Using whole genome sequencing of the relapsing parasite isolates, we identified single nucleotide variants as candidate molecular markers of resistance.
患有间日疟原虫疟疾的患者使用伯氨喹来预防复发感染。我们报告了一名患者在没有再次感染可能的情况下出现 3 次复发的伯氨喹治疗失败。通过对复发寄生虫分离株进行全基因组测序,我们确定了单核苷酸变异作为耐药性的候选分子标记。