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本文引用的文献

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The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum.疟原虫恶性疟原虫比间日疟原虫表现出更大的遗传多样性。
Nat Genet. 2012 Sep;44(9):1046-50. doi: 10.1038/ng.2373. Epub 2012 Aug 5.
2
CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine.CYP450 表型分析和 8-氨基喹啉类抗疟药物伯氨喹代谢产物的精确质量鉴定。
Malar J. 2012 Aug 2;11:259. doi: 10.1186/1475-2875-11-259.
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Relapse of imported Plasmodium vivax malaria is related to primaquine dose: a retrospective study.输入性间日疟原虫疟疾复发与伯氨喹剂量的关系：一项回顾性研究
Malar J. 2012 Jun 22;11:214. doi: 10.1186/1475-2875-11-214.
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Relapse of imported vivax malaria despite standard-dose primaquine therapy: an investigation with molecular genotyping analyses.尽管采用标准剂量的伯氨喹治疗，输入性间日疟仍有复发：一项采用分子基因分型分析的调查。
Clin Microbiol Infect. 2012 Jul;18(7):E232-4. doi: 10.1111/j.1469-0691.2012.03820.x. Epub 2012 Mar 27.
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Human genetic variation is associated with Plasmodium falciparum drug resistance.人类遗传变异与恶性疟原虫抗药性有关。
J Infect Dis. 2011 Dec 1;204(11):1772-8. doi: 10.1093/infdis/jir629. Epub 2011 Oct 12.
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The international limits and population at risk of Plasmodium vivax transmission in 2009.2009 年按蚊传播间日疟原虫的国际界限和危险人群。
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Resistance to therapies for infection by Plasmodium vivax.间日疟原虫感染治疗的耐药性。
Clin Microbiol Rev. 2009 Jul;22(3):508-34. doi: 10.1128/CMR.00008-09.
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New developments in Plasmodium vivax malaria: severe disease and the rise of chloroquine resistance.间日疟原虫疟疾的新进展：重症疾病与氯喹耐药性的上升
Curr Opin Infect Dis. 2009 Oct;22(5):430-5. doi: 10.1097/QCO.0b013e32832f14c1.
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Disruption of a Plasmodium falciparum multidrug resistance-associated protein (PfMRP) alters its fitness and transport of antimalarial drugs and glutathione.恶性疟原虫多药耐药相关蛋白（PfMRP）的破坏会改变其适应性以及抗疟药物和谷胱甘肽的转运。
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Pharmacogenetics of cytochromes P450 in tropical medicine.热带医学中细胞色素P450的药物遗传学
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携疟原虫 1 型对伯氨喹敏感性的基因分析：一位复发型间日疟患者的案例报告

Genetic analysis of primaquine tolerance in a patient with relapsing vivax malaria.

机构信息

University of California, San Diego, La Jolla, CA, USA

出版信息

Emerg Infect Dis. 2013 May;19(5):802-5. doi: 10.3201/eid1905.121852.

DOI:10.3201/eid1905.121852
PMID:23648098
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3647516/
Abstract

Patients with Plasmodium vivax malaria are treated with primaquine to prevent relapse infections. We report primaquine failure in a patient with 3 relapses without any possibility of re-infection. Using whole genome sequencing of the relapsing parasite isolates, we identified single nucleotide variants as candidate molecular markers of resistance.

摘要

患有间日疟原虫疟疾的患者使用伯氨喹来预防复发感染。我们报告了一名患者在没有再次感染可能的情况下出现 3 次复发的伯氨喹治疗失败。通过对复发寄生虫分离株进行全基因组测序，我们确定了单核苷酸变异作为耐药性的候选分子标记。