Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, Seoul, 136-705, South Korea.
Mol Biol Rep. 2013 Aug;40(8):5129-41. doi: 10.1007/s11033-013-2616-1. Epub 2013 May 8.
The aim of this study was to determine whether the toll-like receptor (TLR) and matrix metalloproteinase (MMP) polymorphisms confers susceptibility to periodontitis in ethnically different populations. A literature search using PubMed and Embase provided the data to conduct a meta-analysis on the associations between the TLR2 Arg753Gln, TLR4 Asp299Gly, Thr399Ile, MMP-1 -1607 G1/G2 and MMP-9 -1562 C/T polymorphisms and periodontitis. A total of 32 studies (14 on TLR polymorphisms and 18 on MMP polymorphisms) were considered in the meta-analysis. The meta-analysis showed no association between periodontitis and the TLR2 753Arg allele (Odds ratio [OR]=0.962, 95% confidence interval [CI]=0.662-1.400, p=0.841). Meta-analysis of the TLR4 Asp299Gly and Thr399Ile polymorphisms showed no association between periodontitis and the TLR4 299Asp allele in all study subjects (OR=0.984, 95% CI=0.761-1.271, p=0.900; OR=1.030, 95% CI=0.748-1.418, p=0.854). Meta-analysis showed an association between the MMP-1 -1607 G2G2 genotype and periodontitis in Asians (OR=3.778, 95% CI=1.210-11.80, p=0.022). Meta-analysis containing only studies in Hardy-Weinberg equilibrium revealed no association between chronic periodontitis and the MMP-9 -1562TT genotype (OR=0.638, 95% CI=0.265-1.533, p=0.315). This meta-analysis demonstrates a lack of association between the TLR2 Arg753Gln, TLR4 Asp299Gly, Thr399Ile, MMP-9 -1562 C/T polymorphisms and periodontitis, but shows an association between the MMP-1 -1607 G2G2 genotype and periodontitis in Asians.
本研究旨在确定 Toll 样受体 (TLR) 和基质金属蛋白酶 (MMP) 多态性是否与不同种族人群的牙周炎易感性相关。通过使用 PubMed 和 Embase 进行文献检索，为 TLR2 Arg753Gln、TLR4 Asp299Gly、Thr399Ile、MMP-1 -1607 G1/G2 和 MMP-9 -1562 C/T 多态性与牙周炎之间的关联进行荟萃分析提供了数据。共纳入 32 项研究（14 项关于 TLR 多态性，18 项关于 MMP 多态性）进行荟萃分析。荟萃分析显示，TLR2 753Arg 等位基因与牙周炎之间无关联（优势比 [OR]=0.962，95%置信区间 [CI]=0.662-1.400，p=0.841）。TLR4 Asp299Gly 和 Thr399Ile 多态性的荟萃分析显示，在所有研究对象中，TLR4 299Asp 等位基因与牙周炎之间均无关联（OR=0.984，95%CI=0.761-1.271，p=0.900；OR=1.030，95%CI=0.748-1.418，p=0.854）。荟萃分析显示，MMP-1 -1607 G2G2 基因型与亚洲人群的牙周炎之间存在关联（OR=3.778，95%CI=1.210-11.80，p=0.022）。仅包含 Hardy-Weinberg 平衡研究的荟萃分析显示，慢性牙周炎与 MMP-9 -1562TT 基因型之间无关联（OR=0.638，95%CI=0.265-1.533，p=0.315）。本荟萃分析表明 TLR2 Arg753Gln、TLR4 Asp299Gly、Thr399Ile、MMP-9 -1562 C/T 多态性与牙周炎之间无关联，但 MMP-1 -1607 G2G2 基因型与亚洲人群的牙周炎之间存在关联。
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