Material Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, USA.
Nanoscale. 2013 Jun 21;5(12):5252-6. doi: 10.1039/c3nr00333g.
We report a prototype approach to formulate gold nanoparticle-based X-ray absorbing agents through surface-engineering of a cisplatin pharmacophore with modified polyacrylate. The resulting agents exhibit both chemo-therapeutic potency to cancer cells and Auger-mediated secondary electron emission, showing great potential to improve the therapeutic efficacy of chemo-radiation.
我们报告了一种通过用改性聚丙烯酸对顺铂药效团进行表面工程来制备基于金纳米粒子的 X 射线吸收剂的原型方法。所得到的试剂对癌细胞表现出化学治疗效力和俄歇介导的二次电子发射，显示出改善化学放射治疗疗效的巨大潜力。
