Center for Biomedical Engineering, Brigham and Women's Hospital, Harvard medical School, Cambridge, MA 02115, USA.
Adv Mater. 2013 Jun 25;25(24):3329-36. doi: 10.1002/adma.201300584. Epub 2013 May 13.
Novel silicate nanoplatelets that induce osteogenic differentiation of human mesenchymal stem cells (hMSCs) in the absence of any osteoinductive factor are reported. The presence of the silicate triggers a set of events that follows the temporal pattern of osteogenic differentiation. These findings underscore the potential applications of these silicate nanoplatelets in designing bioactive scaffolds for musculoskeletal tissue engineering.
研究报道了新型硅酸盐纳米片，其在没有任何成骨诱导因子的情况下可诱导人间充质干细胞（hMSCs）的成骨分化。硅酸盐的存在引发了一系列事件，这些事件遵循成骨分化的时间模式。这些发现强调了这些硅酸盐纳米片在设计用于肌肉骨骼组织工程的生物活性支架方面的潜在应用。
