Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
J Cutan Med Surg. 2013 May-Jun;17(3):153-72. doi: 10.2310/7750.2012.12005.
Vitiligo is a commonly encountered pigmentary disorder. Numerous studies and investigations from all over the world have attempted to determine the mechanisms behind this disease; however, the pathogenesis of vitiligo remains elusive.
n this comprehensive review article, we present the findings behind the five overarching theories of what causes this disfiguring and psychologically debilitating disease.
We begin our discussion with the role of genetic predisposition and move onward to the neural theory first proposed in the 1950s. Next we discuss the autoimmune hypothesis, followed by the reactive oxygen species model, and conclude by describing the findings of the more recent melanocytorrhagy hypothesis.
Although the exact pathogenesis of vitiligo is uncertain, each of these theories likely plays a role. Understanding each theory would pave the way for therapeutic advances for this disease.
白癜风是一种常见的色素障碍性疾病。来自世界各地的众多研究试图确定这种疾病背后的机制，但白癜风的发病机制仍难以捉摸。
在这篇全面的综述文章中，我们介绍了导致这种毁容和心理衰弱疾病的五个主要理论的研究结果。
我们从遗传易感性的作用开始讨论，然后转向 20 世纪 50 年代首次提出的神经理论。接下来我们讨论自身免疫假说，然后是活性氧物种模型，最后描述最近的黑素细胞破坏假说的发现。
尽管白癜风的确切发病机制尚不确定，但这些理论都可能发挥作用。了解每个理论都将为这种疾病的治疗进展铺平道路。
